This article defines the term surrogate as an organism, particle, or substance used to study the fate of a pathogen in a specific environment. Pathogenic organisms, nonpathogenic organisms, and innocuous particles have been used as surrogates for a variety of purposes, including studies on survival and transport as well as for method development and as "indicators" of certain conditions. This a...

many real water resources optimization problems involve conflicting objectives. in this study, multiobjective genetic algorithm nsga-ii, has been developed for optimization the conjunctive use of surface water and groundwater resources and optimal management of supply and demand of agricultural water. here, optimal allocation of land and water resources to the dominant products in najaf abad pl...

This paper deals with developing an efficient Robust Design Optimization (RDO) framework. The goal is to obtain an aerodynamic shape that is less sensitive to small random geometry perturbations and to uncertain operational conditions. The initial shape is the RAE2822 airfoil which is parameterized with 10 design variables. The robust design formulation used is based on an expectation measure. ...

Prostate cancer is the most common cancer in men worldwide. To improve future drug development and patient management, surrogate biomarkers associated with relevant outcomes are required. Circulating tumour cells (CTCs) are tumour cells that can enter the circulatory system, and are principally responsible for the development of metastasis at distant sites. In recent years, interest in detectin...

Timely completion of design cycles for complex systems ranging from consumer electronics to hypersonic vehicles relies on rapid simulation-based prototyping. The latter typically involves high-dimensional spaces possibly correlated control variables (CVs) and quantities interest (QoIs) with non-Gaussian multimodal distributions. We develop a model-agnostic, moment-independent global sensitivity...