Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune ...

Abstract Background Immune cells account for a large proportion of the tumour microenvironment in anaplastic thyroid carcinomas (ATCs). However, expression pattern immune-related genes (IRGs) ATCs is unclear. Our study aimed to identify an signature indicating dedifferentiation cells. Methods We compared differences differentiation score (TDS), infiltration immune and enriched pathways between ...

The interaction of immunological system, thyroid and pineal gland was studied in 5-week old males of Gallus domesticus. Several morphometrical parameters in pineal and thyroid glands were measured after bird immunization with human red blood cells and/or treatment with melatonin or seduxen, melatonin receptor blocker. The peak of the thyroid activity was found on Day 7 after immunization. The i...

PURPOSE To study the clinical involvement of the ocular surface and the in vivo morphology of corneal cells and nerves, in patients affected by active and inactive Graves' orbitopathy (GO). METHODS The study included 26 consecutive GO patients and 20 age- and sex-matched healthy control subjects. GO was diagnosed on the basis of the criteria of the European Group on Graves' Orbitopathy, and d...

Increased reactive oxygen species (ROS) generation and the consequent oxidative damage are involved in the development of several diseases, including autoimmune diseases. Graves' disease is an autoimmune disorder characterized by hyperthyroidism and, less frequently, orbitopathy. Hyperthyroidism is characterized by increased oxidative stress. Untreated hyperthyroidism is associated with an incr...

It is also known that RAI treatment can induce an alteration in immune response to thyroid antigens in Graves’ disease (5). Thus it is also possible that thyroid antigens can be released into the circulation after destruction of thyroid cells by RAI in patients with thyroid cancer. Evidence for this comes from our previous study which showed that serum thyroid peroxidase was detectable after RA...

Graves’ Disease (GD) is the most common form of hyperthyroidism. It affects 3% female patients and 0.5% male usually between age 30-60. cause 80% hyperthyroid cases in USA. The pathogenesis disease complex autoimmunity plays a key role. antibodies stimulating thyrotropin receptor (TRAb) lead to uncontrolled Thyroid-stimulating Hormone (TSH) overproduction thyroid hormones from overactive gland....

PURPOSE To report the clinical features of strabismus associated with Graves' orbitopathy, and the results of surgery with adjustable suture under drop anesthesia. METHODS The charts of 13 patients who had surgical treatment for strabismus related to Graves' orbitopathy at Hospital das Clínicas of University of São Paulo were retrospectively reviewed. Ocular motility, sensorial examination an...