purpose: to evaluate the prevalence and severity of ophthalmic manifestations of graves’ disease in the mashhad university of medical sciences endocrine clinics . methods: in a multicenter prospective-descriptive study, patients with graves' disease that were being followed in mashhad university of medical sciences endocrine clinics were recruited for the study, from december 2002 to septe...

Graves' thyroid disease is a relatively common disorder in endocrinology and general internal medicine practice. Graves' hyperthyroidism is mediated by circulating stimulating autoantibodies. Up to 60% of patients with Graves' hyperthyroidism develop some form of Graves' orbitopathy. Immune reactivity to the thyroid-stimulating hormone receptor is also thought to play a role in the immunopathog...

BACKGROUND AND OBJECTIVE To investigate the incidence and outcome of optic neuropathy associated with thyroid-related orbitopathy. PATIENTS AND METHODS All patients diagnosed as having optic neuropathy associated with thyroid-related orbitopathy who underwent treatment for optic neuropathy between January 1, 1999, and March 1, 2003, were reviewed. Demographic and clinical data were extracted ...

BACKGROUND Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease. CASE PRESENTATION A 25-year-old woman has been referred to the endocrino...

Ophthalmopathy is one of the known presenting features of Grave’s disease. Its due to development of antithyroid receptor antibodies. Rarely it may be associated with thyroid malignancies developing in the Grave’s nodule. There are few case reports of patients with coexisting thyroid associated orbitopathy (TAO) and thyroid carcinoma. Sometimes it may be the presenting symptom of an occult thyr...

Thyroid orbitopathy (thyroid associated orbitopathy or Graves’ ophthalmopathy) is a common cause of proptosis, eyelid retraction, orbital congestion, and motility disturbances in adults. Each patient experiences a unique combination of symptoms and signs for an unpredictable duration and with varying severity. Although orbital manifestations typically improve within 2–5 years, these years feel ...

Dysthyroid orbitopathy (thyroid-associated orbitopathy or Graves’ ophthalmopathy) is the most common cause of both unilateral and bilateral proptosis in adults. This proptosis is usually accompanied by eyelid retraction, orbital congestion or motility disturbances. Each patient experiences a unique combination of symptoms and signs for an unpredictable duration and with varying severity. Althou...

Certain cases of thyroid-related orbitopathy may require surgical decompression of the orbit. The purpose of this paper is to highlight new techniques of orbital decompression in thyroid-related orbitopathy. We present two illustrative cases selected from our recent surgical experience. The techniques of combined-approach decompression, transcaruncular approach to the medial orbital wall, drill...

we determined the frequency of clinical thyroid ophthalmopathy in iranian patients. this cross-sectional study was performed at the endocrinology institute of tehran university of medical sciences. all patients with documented thyroid disorders from september 2003 to july 2005 were recruited. eye examinations included evaluation of soft tissue changes, measurement of proptosis, lid width, lagop...