Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating the role of TL and relevant genes in diabetes development. In the multiethnic Women's Health Initiative, we identified 1,675 incident diabetes case participants in 6 years of follow-up and 2,382 control participants matched by age, ethnicity, cl...

Cys synthesis in plants takes place in plastids, cytosol, and mitochondria. Why Cys synthesis is required in all compartments with autonomous protein biosynthesis and whether Cys is exchanged between them has remained enigmatic. This question was addressed using Arabidopsis thaliana T-DNA insertion lines deficient in the final step of Cys biosynthesis catalyzed by the enzyme O-acetylserine(thio...

5 The Proof of Theorem 2.1. 27 5.1 Estimates for Tl,m, l ≥ 0, m < −l. . . . . . . . . . . . . . . . . . . . . . . . . . 29 5.2 Estimates for Tl,m, l ≥ 0, m > 0. . . . . . . . . . . . . . . . . . . . . . . . . . . 31 5.3 Estimates for Tl,m, l ≥ 0, −l ≤ m ≤ 0. . . . . . . . . . . . . . . . . . . . . . . . 33 5.4 Estimates for T (ε) l R −1 i0 , l ≥ 0. . . . . . . . . . . . . . . . . . . . . . . . ...

Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.

We use a femtosecond pump-probe Z-scan technique to measure the thermal lens (TL) signal in a homologous series of primary alcohols. The trend in these experimentally measured TL signals deviates in a counterintuitive manner from the ones calculated using theoretical models that are only based on the macroscopic parameters. Introspection shows that the present TL theories are based on heat cond...

Patch clamp experiments on single MaxiK channels expressed in HEK293 cells were performed at high temporal resolution (50-kHz filter) in asymmetrical solutions containing 0, 25, 50, or 150 mM Tl+ on the luminal or cytosolic side with [K+] + [Tl+] = 150 mM and 150 mM K+ on the other side. Outward current in the presence of cytosolic Tl+ did not show fast gating behavior that was significantly di...