نتایج جستجو برای: topical 3 diclofenac gel
تعداد نتایج: 1928814 فیلتر نتایج به سال:
PURPOSE To evaluate the pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) in the retinochoroidal tissues of rabbits. METHODS The cyclooxygenase (COX) inhibitory activity of diclofenac, bromfenac, and amfenac, an active metabolite of nepafenac, were determined using human-derived COX-1 and COX-2. Each of the three NSAIDs was applied topically to r...
The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property o...
Background and purpose: Several adverse effects were reported for oral sildenafil. In this research after formulation of sildenafil topical gel, the effect of gel was compared with sildenafil tablet in a double-blind placebo-controled clinical trial. Materials and methods: After choosing the solvent system, several formulations were prepared and the most suitable gel was chosen for clinica...
Introduction: Burns represent a large number of skin injuries. They have a wide variety of factors and they impose financial expenses and psychological damage. Wound infection control is one of the major problems in thermal injuries. The skin, that is the body’s main barrier against the preparation of bacteria, will be damaged during burn. In addition to causing pain, irritation, and inflammati...
BACKGROUND Rosacea is a chronic skin disease that requires long-term therapy. Oral antibiotics and topical metronidazole successfully treat rosacea. Because long-term use of systemic antibiotics carries risks for systemic complications and adverse reactions, topical treatments are preferred. OBJECTIVE To determine if the use of topical metronidazole gel (Metrogel) could prevent relapse of mod...
Purpose: To evaluate the effect of topical application of fluoride gel on artificial secondary caries around adhesive restorations. Materials and Methods: Two box-shaped cavities were prepared on both buccal and lingual dentin surfaces of bovine roots. Each cavity was restored with either a non fluoride-releasing adhesive, Clearfil SE Bond/a resin composite, Clearfil AP-X (AP-X), or an experime...
Actinic keratosis is currently considered not to be a precursor of squamous cell carcinoma but, rather, an initial stage of the disease. Furthermore, the incidence of both squamous cell carcinoma and basal cell carcinoma continues to increase. Topical drugs are now becoming widely used in the therapeutic management of nonmelanoma skin cancer and its precursor lesions. Here, we review the variou...
NEW DRUGS Mirvasco for Rosacea Brimonidine topical gel 0.33% (Mirvasco, Galderma) has been approved for the topical treatment of the facial erythema of rosacea in adults 18 years of age and older. Applied once daily, the medication reduces redness of the face and lasts up to 12 hours. An alpha2-adrenergic agonist, brimonidine appears to constrict the dilated facial blood vessels, which reduces ...
The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 % (m/m) EGCG were prepared and subjected to photodegradation studies in order to select excipients that minimize the light i...
PURPOSE OF REVIEW Topical therapeutic approaches in localized neuropathic pain (LNP) syndromes are increasingly used by both specialists and general practitioners, with a potentially promising effect on pain reduction. In this narrative review, we describe the available compounds for topical use in LNP syndromes and address their potential efficacy according to the literature. RECENT FINDINGS...
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