As part of our endeavor to enhance survival of natural product derived drug candidates and to guide the medicinal chemist to design higher probability space for success in the anti cancer drug development area, we embarked on a detailed study of the property space for a collection of natural product derived anti cancer molecules. We carried out a comprehensive analysis of properties for 24 natu...

Two dimensional quantitative structure activity relationship (2D-QSAR) study was performed on B-ring trifluoromethylated chromenone (flavonoid) analogues as anticancer agents. This study was performed with 25 compounds (data set) using random and manual data selection methods for the division of the data set into training and test set. Multiple linear regression analysis coupled with stepwise v...

Purpose: To analyze 68 Ga-PSMA-617 PET/CT or PET/MR and delayed images in patients diagnosed with suspicion of prostate cancer, to explore the optimal use for initial diagnosis staging cancer. Methods: Images from conventional scan by Ga-PSMA whole-body followed pelvic were retrospectively analyzed. Prostatic uptake was measured as SUVmax1 (conventional 1 h post injection) SUVmax2 (delayed 3 in...

By combining information such as genomics, proteomics, and metabolomics data, multiomics methodologies have the potential to reveal otherwise invisible processes of carcinogenesis. Using these a new-generation point-of-care (POC) device may support patient care through rapid diagnosis involving accurate simultaneous measurements. In this work, we present proof-of-concept portable system capable...

Background: Obesity is a major problem that many individuals suffer presently. Using in silico Tools and Servers, we propose to build novel chemical drug validate its oral toxicity effect. Our strategy entails first picking an existing anti-obesity 2-methyl-1-phenylpropan-2- amine as well agent which then coupled with the lithium; bis(trimethylsilyl) utilizing cheminformatics software tools. Ma...

Background. There is a lack of expertise in the procedure of open radical retropubic prostatectomy in West Africa therefore necessitating the training of urologists in the subregion in this procedure. Aim. This report looks at the early outcomes of a single surgeon in this procedure after an SIU fellowship. Methodology. A prospective study of the initial twenty consecutive patients with clinica...

Molecular polar surface (PS) descriptors are very useful parameters in prediction of drug transport properties. They could be also used to investigate the blood-brain barrier (BBB) permeation rate for various chemical compounds. In this study, a dataset of drugs (n = 19) from various pharmacological groups was studied to estimate their potential properties to permeate across the BBB. Experiment...

The Prostate Health Index (PHI) has been used increasingly in the context of prostate cancer (PCa) diagnostics since 2010. Previous studies have shown an association between PHI and a tumor volume of >0.5 cm³. The aim of this study was to investigate the correlation between PHI and tumor volume as well as the Gleason score. A total of 196 selected patients with prostate cancer treated with radi...

Malaria, one of the most widespread diseases, is caused by a plasmodium parasite million people each year, results in several million deaths annually. protozoa that cause malaria, no one antimalarial drug is effective against all four species. research investigation, we performed antimalarial agents. To design a new molecule having good pha information. Key-words: TPSA, GPCR, ADMETox, Malaria i...