After liver surgery, two patients developed unexplainable prolonged prothrombin times (PT) that were not associated with bleeding tendency. The substitution of rabbit thromboplastin for either human or monkey thromboplastin in performing PT tests resulted in a normal clotting time. Tissue factor (TF) procoagulant activity assays and an immunoblotting analysis showed that these patients had deve...

The hypothesis that transfer factor (TF) is an antibody-like molecule, possibly related to the T-cell receptor, has been explored. Experiments to test the hypothesis have involved determining whether TF can act as an antigen-dependent macrophage inhibition factor(MIF). Peritoneal exudate cells from normal guinea-pigs were migrated from capillary tubes in the presence and absence ofPPD and of 'd...

Rabbits were given polyclonal anti-tissue factor (TF) immunoglobulin G (IgG) before an injection of endotoxin to test the hypothesis that TF triggers disseminated intravascular coagulation (DIC) after endotoxin. The rabbits had been prepared with cortisone to develop DIC after one injection of endotoxin. Anti-TF IgG substantially reduced the falls in fibrinogen, factors V and VIII, and platelet...

Tissue factor (TF) initiates the coagulation cascade but also plays a role in cancer and metastasis. This transmembrane protein is frequently upregulated on tumor cells and cells that show metastatic behavior. Furthermore, it is a significant risk factor for hepatic metastasis in patients suffering from colon cancer. Recently, it has been shown that TF, together with its natural ligand factor V...

An association between cancer and thrombosis has been recognized for more than a century. However, the manner by which tumor growth is regulated by coagulation in vivo remains unclear. To assess the role of coagulation on tumor growth, in vivo, we tested coagulation inhibitors specific for either tissue factor (TF)/factor VIIa (fVIIa) complexes or factor Xa (fXa) for antitumor activity. Here, w...

Ferula haussknechtii H. Wolff ex Rech.F. is an important medicinal plant belonging to the Apiaceae, family. In order to investigate the effect of Pb on the growth, chemical composition of essential oil and accumulation of metals in this species, a pot study was conducted under glasshouse condition. Seeds were collected from natural rangelands of Lorestan province, Iran in summer 2016. ...

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 a member of the 70 heat shock family proteins involved in correcting and clearing misfolded ER. In response to cellular stress, escapes from ER moves plasma membrane where it (a) functions as receptor for many ligands, (b) behaves autoantigen autoantibodies that contribute human dis...

Arsenic is a nonessential element for plants; however, high levels of As can inhibit plant growth. The toxicity influenced mainly by its speciation in soil. objectives the present study were to determine fractional composition soil, accumulation plants, and potentially toxic effects on morphological, anatomical, ultrastructural levels. In model experiment, barley (Hordeum sativum L.) was plante...

Inactivation of the murine tissue factor (TF) gene or tissue factor pathway inhibitor 1 (TFPI) gene results in embryonic lethality, indicating that both are required for embryonic development. We have shown that expression of low levels of TF from a transgene (hTF) rescues TF-null embryos. However, low-TF mice (mTF(-/-)/hTF+) have hemostatic defects in the uterus, placenta, heart, and lung. In ...