A 69 yr old female was hospitalized for further examination of abnormal shadows on chest radiographs. She had a history of tuberculous pleurisy, rheumatoid arthritis and gold-induced interstitial pneumonia. On admission she still suffered from rheumatoid arthritis. A chest computed tomography scan on admission showed clusters of small nodules in subpleural regions of both lungs combined with br...

Background Disseminated tuberculosis is an uncommon but devastating form of tuberculosis, possibly developing with the immune response patients. COVID-19 infection may produce immunosuppressive effect possible implications for dissemination. Case presentation A 17-year-old female patient a history tuberculous pleurisy presented to hospital high fever and life-threatening dyspnea after contracti...

The characteristics and function of human lymphocytes at a morbid site were studied. Exudative-sensitized lymphocytes in tuberculous pleural fluid reacted to the specific antigen more effectively and produced higher titers of lymphokines including interferon gamma (IFN-gamma) and interleukin 2 (IL-2) than circulating lymphocytes. CD4+/CD8- T-cell subset is responsible for the antigen-specific I...

Some patients with active tuberculosis lack a delayed skin test reaction to PPD (1-4). The basis for this immunologic hyporesponsiveness has been investigated using in vitro systems. Tuberculin-induced blastogenic responses of lymphocytes are decreased in such patients compared with healthy tuberculin reactors (5, 6). This is not simply due to a dearth of responsive cells in the circulation. Ra...

BACKGROUND The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE. METHODS Primary diagnostic test...

Background/Purpose Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis. The aim of this study is to analyze associates and predictors of pleurisy versus pericarditis in Caucasians and African Americans with SL...