Background: Study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. This paper reports the prostacyclin concentration changes after low-moderate doses of X-irradiation within a short period of time. Materials and Methods: Cervical cords of Wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 Gy X-rays. After 24 hours, 2 and 13 ...

Postural orthostatic tachycardia syndrome (POTS) is common in children, with an excessive increment heart rate when moving from the supine to upright position. It has significant negative impacts on daily life of pediatric patients. The pathogenesis POTS includes peripheral vascular dysfunction, central hypovolemia, abnormal autonomic function, a high-adrenergic state, impaired skeletal-muscle ...

Failure of hemodialysis access is caused mostly by venous intimal hyperplasia, a fibro-muscular thickening of the vessel wall. The pathogenesis of venous neointimal hyperplasia in primary arteriovenous fistulae consists of processes that have been identified as upstream and downstream events. Upstream events are the initial events producing injury of the endothelial layer (surgical trauma, hemo...

Background: Fibrinogen is a glycoprotein produced by the liver that plays crucial role in blood clotting. Elevated levels of fibrinogen have been associated with an increased risk cardio vascular disease, stroke and other chronic conditions. Several studies investigated relationship between diabetes mellitus. Furthermore, has suggested to play pathogenesis its complications promoting inflammati...

Numerous studies indicate that with the chronic effect of trinitrotoluene (TNT, TNT) on human body, peculiar specific opacities appear in lens [1, 2, 3, 4, 5, 6, 7, 10 Despite accumulated material clinic trotyl cataract, change organ vision as a whole during poisoning has not been studied enough. There is no unified classification lens, issue pathogenesis toxic cataracts finally resolved, insuf...

Previous studies have shown that accumulation of tumor ascites fluid results in large part from increased permeability of peritoneal lining vessels (Nagy et al., Cancer Res., 49: 5449-5458, 1989; Nagy et al., Cancer Res., 53: 2631-2643, 1993). However, the specific microvessels rendered hyperpermeable have not been identified nor has the basis of peritoneal vascular hyperpermeability been estab...