Background & Aim:  Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. The adverse effects they produce in the gastrointestinal tract however, often limit their utility. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. In view of this, the effect of thyme essential oil, an agent with anti-o...

this experiment was conducted to compare the effects of multi-strain probiotic inclusion levels on performance, intestinal morphology, gut microflora and hematological changes in salmonella typhimurium (st) infected broiler chickens. a total of 120 day old ross 308 broiler chickens were distributed into 20 floor pens and reared for 10 days under 5 experimental treatments including a corn-soy ba...

BACKGROUND The functions of urokinase in intestinal epithelia are unknown. AIMS To determine the relation of urokinase expressed by intestinal epithelial cells to their position in the crypt-villus/surface axis and of mucosal urokinase activity to epithelial proliferative kinetics in the distal colon. METHODS Urokinase expression was examined immunohistochemically in human intestinal mucosa...

The incidence of pancreatic cancer is increased in patients who have undergone gastric surgery. An animal model is described in which pancreatic hyperplasia and adenoma formation developed within 56 weeks. The effects of a simple gastrojejunostomy were compared with those after a split gastrojejunostomy, in which the jejunum was transected and the two limbs implanted separately into the greater...

INTRODUCTION hepatectomy, both partial resection and transplant, has greatly developed and advanced during the last years as a result of a better understanding of surgical anatomy and the progress of technological means; it has also allowed a widening of surgical indications, including living-donor liver transplantation. The aims of our study was to assess the morphological impact of partial he...

BACKGROUND The role of intestinal glucose absorption in reducing glycemic levels after duodenojejunal bypass (DJB) is unclear. We hypothesized that DJB surgery decreases intestinal electrogenic glucose absorption by sodium glucose co-transporter 1 (SGLT1), leading to decreased glucose absorption and reduced blood glucose. Six groups of C57/BL6 mice were studied (n = 6 each) 2 weeks, 1 month, an...

Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mice. Different levels of Sox9-EGFP permit analyses of active IESC (Sox9-EGFPLow), activatable reserve IESC and enteroendocrine cells (Sox9-EGFPHigh),...

Chorionic villus sampling has gained importance as a tool for early cytogenetic diagnosis with a shift toward first trimester screening. First trimester screening using nuchal translucency and biomarkers is effective for screening. Chorionic villus sampling generally is performed at 10-12 weeks by either the transcervical or transabdominal approach. There are two methods of analysis; the direct...