The neuropsychiatric states of 50 patients with vitamin B12 deficiency and 34 patients with folate deficiency presenting with megaloblastosis in a general hospital were examined and compared. Abnormalities of the nervous system were found in two-thirds of both groups. Peripheral neuropathy was the most common condition associated with vitamin B12 deficiency and affective disorder with folate de...

By S. J. BAKER, V. I. MATHAN AND K. ABE H YPERPIGMENTATION OF THE SKIN in Indian patients with megaloblastic anemia appears to have been first documented by Cook.1 Studies from this unit suggested that this was often associated with vitamin B12 deficiency,2’3 though more recent studies following the introduction of folic acid assays, have shown that it can also occur in some cases of pure folat...

Spinal cord injury (SCI) is damage to the spinal cord that leads to sudden loss of motor and autonomic function and sensory under the level of the injury. Studies showed that individuals with SCI has a clear tendency to vitamins level change. The aim of this study was to review the vitamins level in spinal cord injury. Vitamins C level decrease in the injured spinal cord patient. Vitamins C hav...

OBJECTIVE To consolidate information available on the effect of vitamin B12 on bone mineral density and fracture risk, with emphasis on clinical trials, observational and longitudinal data conducted in humans. METHOD A systematic review of the literature of the past decade on the role of vitamin B12 in bone mineral density and fracture risk in subjects of all ages and both sexes was performed...

BACKGROUND/AIMS Inflammatory bowel disease (IBD) primarily involves the intestinal tract and can affect vitamin absorption. This study was designed to assess the prevalence of vitamin B12 and folate deficiencies in patients with IBD, and to identify the risk factors associated with abnormal serum vitamin B12 and folate levels. METHODS We evaluated the medical records of 195 patients with Croh...

our findings is that the concentration of HC is influenced by the vitamin B12 status of the patient. The issue has important implications for the interpretation of low cobalamin in relation to low HC concentrations in patients undergoing examination for vitamin B12 deficiency. If genetic factors were the only regulators of the HC concentration, the physician could decide that the low concentrat...

We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. Some patients with vitamin B12 deficiency may benefit from high dose folic acid supplementation, even if plasma concentrations are high.

Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely reported in literature. We aimed to report a case in a 51 year old woman, who presented with fever and pancytopenia and was diagnosed to have megaloblastic anemia secondary to vitamin B12 and folate deficiency. The pyrexia subsided following the intramuscular injection of vitamin B12 and oral folic acid a...

II ECOGNITION of the fully-developed megaloblast in deficiency of vitamm B12 or folic acid is not difficult. In the case of the “intermediate megaloblast” or “megaloblastoid” cell, however, identification of megaloblastic changes often becomes more difficult, and more subjective.1 The present study attempts to reduce this subjectivity by demonstrating a unique clockface chromatin pattern along ...

II ECOGNITION of the fully-developed megaloblast in deficiency of vitamm B12 or folic acid is not difficult. In the case of the “intermediate megaloblast” or “megaloblastoid” cell, however, identification of megaloblastic changes often becomes more difficult, and more subjective.1 The present study attempts to reduce this subjectivity by demonstrating a unique clockface chromatin pattern along ...