When the Global Polio Eradication Initiative was launched in 1988, there were more than 350 000 cases a year in more than 125 countries. In 2003, there were just 784 cases. This year will be critical for the initiative led by WHO, Rotary International, US Centers for Disease Control and Prevention and UNICEF. If vaccination campaigns can immunize all children in Afghanistan, India, Nigeria and ...

In several recent conferences, the principal questions have been whether xenotransplantation technology should be encouraged and, if so, how it should be regulated. Because the prospect of successful transplantation of animal organs into humans is still remote, the rush to achieve consensus about clinical application would be inexplicable were it not for two ostensibly unrelated issues. The fir...

Cancer cells rapidly evolve a multitude of defense mechanisms to evade the effects of the oncologist's drug arsenal. Unfortunately, clinical strategies to overcome these lag far behind. This mismatch likely underlies our inability to implement new durable treatment strategies. Here, a new form of multidrug resistance, inducible drug glucuronidation, is discussed. This form was discovered while ...

Artificial intelligence started with the goal of understanding minds by attempting to build them. This essay discussed how our field’s research has become unbalanced, and what might be done to change this situation. Specifically, I argue that more of our efforts should be focused on creating integrated cognitive systems. The founding of this journal will hopefully help by promoting such research.

kidney disease (CKD) adds to their prognostic evaluation in terms of mortality. They conclude that the determination of inflammatory markers is not helpful if age and comorbidity are taken into account. It would, however, be appropriate if some further analyses were performed before such a conclusion is advanced. The conclusion of Caravaca et al. [1] is based on a multivariate Cox-regression an...