Ethylene glycol (CAS RN 107-21-1) can cause kidney toxicity via the formation of calcium oxalate crystals in a variety of species, including humans. Numerous repeated dose studies conducted in rats have indicated that male rats are more susceptible than female rats. Furthermore, subchronic and chronic studies using different dietary exposure regimens have indicated that male Wistar rats may be ...

UNLABELLED The renin-angiotensin system plays a crucial role in the regulation of cardiovascular function and maintenance of water-electrolyte balance. The two major receptor types of the system, AT1 and AT2, have different, often opposite effects on these functions. AIM To elucidate the impact of long-term treatment with selective angiotensin receptor antagonists and an agonist on water-salt...

background: the purpose of the present study was to investigate the effect of endurance training on amount of nicotinic acetylcholine receptors (nachr) in fast and slow twitch muscles of male wistar rats. methods: a number of 15 male wistar rats randomly divided into two groups of control (n=7) and endurance training (n=8). the endurance training treadmill running (for 12 consecutive week, 5 da...

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids can lower decrease thickening. To determine the effect of bay (Syzygiumpolyanthum) on ventricle thickening rat (Rattus norvegicus wistar strain) in hypertensive model. T...

Hematopoietic stem cell transplantation patients conditioned with cyclophosphamide (CY) and total body irradiation have substantially greater risk of nonrelapse mortality when plasma area under the concentration-time curve (AUC) of O-carboxyethylcyclophosphoramide mustard (CEPM) is high. The discovery was paradoxical because CEPM is a nontoxic elimination route of the protoxic CY metabolite hyd...

introduction: the aim of this work was to evaluate the effects of four different concentrations of aloe vera extract on healing of second degree burns in male wistar rats. materials and methods: by an experimental study 42 male wistar rats were divided into 7 equal groups. the burn injury was made on the back of all rats, according to standard methods. the burned areas in the group1: were left ...

BACKGROUND The present study was undertaken to evaluate the antihyperglycemic, antihyperlipidemic and hepatoprotective effect of a traditional unani formulation "Qurs Tabasheer" in streptozotocin (STZ) induced diabetic wistar rats. Up till now no study was undertaken to appraise the efficacy of "Qurs Tabasheer" in the diabetic rats. Qurs Tabasheer is a unani formulation restraining preparations...

BACKGROUND Paradoxical sleep deprivation (PSD) associated with cocaine has been shown to enhance genital reflexes (penile erection-PE and ejaculation-EJ) in Wistar rats. Since hypertension predisposes males to erectile dysfunction, the aim of the present study was to investigate the effects of PSD on genital reflexes in the spontaneously hypertensive rat (SHR) compared to the Wistar strain. We ...