Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration. S1P functions as a trophic factor for many cell types, including embryonic stem cells (ESCs). Sphingosine phosphate lyase (SPL) is an intracellular enzyme that catalyzes the irreversible degr...

Objetivo: Avaliar o a influência da remoção de resíduos dois cimentos à base resina epóxi (SPL, Sealer Plus ou S26, 26), com etanol 95% (ETA) xilol (XIL), na interface adesão entre sistema adesivo universal (SBU, Scotchbond Universal), utilizado estratégia condiciona-e-lava, e substrato dentinário coroa dental, por meio avaliação resistência união (RU), avaliada pelo teste microcisalhamento, an...

Bats lower the emission SPL when approaching a target. The SPL reduction has been explained by intensity compensation which implies that bats adjust the emission SPL to perceive the retuning echoes at the same level. For a better understanding of this control mechanism we recorded the echolocation signals of four Myotis myotis with an onboard microphone when foraging in the passive mode for rus...

This paper examines possibilities and consequences of introducing variability with respect to pricing, accounting, and way of payment into software product lines for developers, vendors, and customers. The global goal is the derivation of an extensible conceptual framework for vendors of SPLs which adds relevant economic variability to the SPL. The capability of economic methods for pricing and...

The software product line (SPL) community defines SPLs not only by technical aspects like configurability and code reuse among product line variants, but also by the engineering process that accompanies the development. This paper discusses the question whether this engineering process is a mandatory property of SPLs; it concretely examines the Linux Kernel, which is not being developed accordi...

The goal was to identify sound pressure level (SPL) at the neonatal intensive care unit (NICU) and inside the incubator of a teaching hospital of a public university from São Paulo - SP, Brazil. SPL inside the NICU and the incubator were measured using four dosimeters in January/2010. SPL at the NICU varied from 52.6 dBA to 80.4 dBA and inside the incubator, from 45.4 dBA to 79.1 dBA. SPL both ...