نتایج جستجو برای: ژن tp53
تعداد نتایج: 23956 فیلتر نتایج به سال:
the tp53 gene is one of the most frequently mutated genes amongst human malignancies, particularly tp53 codon 72 polymorphism. furthermore, an association between the tp53 codon 72 variants and prostate cancer has been reported in several studies. although some studies have indicated an association between the tp53 arg/arg variant and an increased risk for prostate cancer, other studies have sh...
objective: to review her-2/neu and tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. materials and methods: this cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between may 2000 and march 2006 at the surgery and pathology departments of alzahra hospital...
زمینه و هدف: گیاه حرا (avicennia marina) یکی از گیاهان دارویی ایران و از اعضای خانواده آکانتاسه است که در مناطق حاره ای و نیمه حاره ای می روید. هدف از این مطالعه بررسی اثرات ضد سرطانی و ضد باکتریایی عصاره های مختلف برگ گیاه حرا است. در این پژوهش مکانیسم اثر ضد سرطانی یک فراکسیون جداسازی شده از عصاره متانولی بر روی سلول های سرطان سینه انسانی بررسی گردید. روش ها: برگ گیاه حرا در فروردین ماه سال 1...
Objective: To review Her-2/neu and Tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. Materials and Methods: This cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between May 2000 and March 2006 at the surgery and pathology departments of Alzahra Hosp...
background: the tp53 gene is the most important tumor suppressor gene in humans. the aim of our study was to determine the genotype frequency of three common tp53 polymorphisms (codon 72 bstui and intron 6 mspi, as well as the intron 3) in a group of iranian women with and without breast cancer. methods: paraffin-embedded specimens of 65 malignant breast cancer cases and 65 cases with benign br...
the tp53 tumor suppressor gene plays important roles in genomic stability. a common polymorphism at codon 72 of tp53 gene has been associated with increased risk for many human cancers. the p53 protein is expressed in colorectal cancer, but the reported prevalence of its expression varies widely. in the present study, the p53 protein expression in different genotypes of its codon 72 , was inves...
BACKGROUND TP53 defects, i.e., 17p13 deletion and/or nucleotide mutations, associate with short survival and chemorefractoriness in chronic lymphocytic leukemia (CLL). In this context, since direct sequencing of the TP53 gene does not evaluate TP53 functionality, a functional assessment of TP53 pathway may be of interest to identify high risk CLL. By taking advantage of a training cohort of 100...
سرطان روده بزرگ یکی از معمولیترین بدخیمی¬های موجود درکشورهای توسعه یافته است که بعنوان سومین نوع سرطان منجر به مرگ در کشورهای غربی شناخته شده است. میزان شیوع سالیانه آن در انگلستان 3500 نفر و در کل دنیا نیم میلیون نفر تخمین زده می¬شود که معادل 13% کل سرطان¬ها می باشد. سالانه حدود 55000 نفر بخاطر سرطان روده بزرگ در ایالات متحده آمریکا می¬میرند. تخمین زده شده است که هر سال 19000 و 160000 مورد جدی...
Background: Molecular marker based cancer diagnosis gaining more attention in the current genomics era. So, Hspb1 and Tp53 gene characterization and their mRNA expression might be helpful in diagnosis andprognosis ofcat mammary adenocarcinoma. It will also add informationin comparative cancer genetics and genomics. Objectives: Eight tumors of Siamese cats were analyzed to ascertain germ-line an...
Gastric cancer (GC) is one of the leading causes of cancer mortality, worldwide. Molecular understanding of GC’s different subtypes is still dismal and it is necessary to develop new subtype-specific diagnostic and therapeutic approaches. Therefore developing comprehensive research in this area is demanding to have a deeper insight into molecular processes, underlying these subtypes. In this st...
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