a graphene nanosheets (gns) film coated glassy carbon electrode (gce) was fabricated for sensitive determination of tyrosine (tyr). the gns-based sensor was characterized by scanning electron microscope and electrochemical impedance spectroscopy. the voltammetric techniques were employed to study electro-oxidation of tyr. the results revealed that the modified electrode showed an electrocatalyt...

Recent evidence suggests that oxidative stress (OS) plays an important role in the pathogenesis of congenital heart defect (CHD). The aim this study is to evaluate protein OS biomarkers amniotic fluid fetuses with isolated major CHD. This a retrospective including 92 samples, 50 cases diagnosis CHD and 42 controls (fetuses high risk genetic anomaly or extracardiac malformations, excluding CNS r...

Hypertension is a serious risk factor for various diseases. Therefore, lowering and preventing high blood pressure significant issue. Blockage of the renin-angiotensin-aldosterone system (RAAS), which controls pressure, important to reduce consequently symptoms heart failure. This blockage can be carried out by angiotensin-converting enzyme (ACE) angiotensin II receptor blockers (ARBs). The phe...

The plethora of theories in the field of UX can be highly relevant to practice. This paper discusses the successful use of seven theories in the evaluation of TAPT, an experience-oriented design method. Four models of experience and one discussion of working practice and UX were used for direct evaluation; two other theories drove the methodology of TAPT’s evaluation.

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [39]) are activated the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin may be used to label NTS1 0.1-0.3 3-5 nM concentrations...

somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. in this study tyr³-octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-boc-hydrazinopyridine-3-carboxylic acid (boc-hynic) and after deprotecting of conjugate, purification was performed with prep...

The influences of ?-? interactions in phycocyanin proteins and their environmental preferences were analyzed. observations indicate that the majority aromatic residues are involved interactions. Phenylalanine (Phe) tyrosine (Tyr) found to be ??? much more frequently than tryptophan (Trp) or histidine (His). Similarly, Phe-Phe Tyr-Tyr interacting pair had highest frequency occurrence. In additio...