A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated. Structure-activity relationship analysis revealed that substituted isoquinolinones bearing a 3-methoxybenzyloxyl group at C5, C6 or C7 position respectively (C5>C6>C7 in terms of their potency) conferred effective binding a...

A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of Mt2 and Mt3 was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of ...

Matrix metalloproteinases (MMPs) are a family of important proteolytic enzymes that play an important role in the remodeling of the tumor microenvironment and associate with tumorigenesis and metastasis. We previously reported that membrane type-2 MMP (MT2-MMP) is highly expressed in human esophageal cancer tissues, and its expression level is positively correlated to tumor size and intratumora...

We compare mT2 with mCT ; both are kinematic variables designed to find relationships between masses of pair-produced new states with symmetric decay chains. We find that for massless visible particles mCT equals mT2 in a particular limit. We identify advantages and disadvantages to the use of each variable. Tovey’s paper on mCT also introduced a powerful concept of extracting mass information ...

We propose an inclusive analysis of a stransverse mass (mT2) using a hemisphere method for supersymmetry studies at the LHC . The hemisphere method is an algorithm to group collinear and high pT particles and jets, assuming that there are two of such groups in a event. The mT2 is defined as a function of the unknown LSP mass, two hemisphere momenta, and missing transverse momentum. The kinemati...

Melatonin (Mel) and its receptors (MT1 and MT2) have a well-documented efficacy in treating different pain conditions. However, the anti-nociceptive effects of Mel and Mel receptors in neuropathic pain (NP) are poorly understood. To elucidate this process, pain behaviors were measured in a dorsal root ganglia (DRG)-friendly sciatic nerve cuffing model. We detected up-regulation of MT2 expressio...

Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries. This study examined the role of melatonin receptors in the neuroprotective effects of estrogen. Materials and Methods: Seventy female ovariectomized Wistar rats were divided in...

Heavy metal toxicity poses a harmful threat to plants. Cadmium is non-essential heavy which enters plant cell via soil as result of human malpractices, pollution and industrial works causes severe damage Our study focuses on the effects stress in Plantago ovata (P. ovata) by observing content Phytochelatin 2 (PC2) expression Metallothionein (MT2) gene, both chelating agents. We observed impact ...

In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In the liver, melatonin suppresses oxidative damage and ameliorates fibrosis. No information exists...