BACKGROUND DA-1229 is a novel, potent and selective dipeptidyl peptidase-4 (DPP-IV) inhibitor that is orally bioavailable. We aimed to evaluate the optimal dose, efficacy and safety of DA-1229, in Korean subjects with type 2 diabetes mellitus suboptimally controlled with diet and exercise. METHODS We enrolled 158 patients (mean age, 53 years and a mean BMI, 25.6 kg/m(2) ). The mean baseline f...

Aim: Most endodontic sealers show antimicrobial activity before setting, but most of them also lose this ability after setting. Addition of an antibiotic may affect the properties of sealers such as sealing ability, setting time, and so on. The aim of this study was to assess whether the addition of antibiotics (amoxicillin, doxycycline, and clindamycin) improves the sealing ability of AH 26 se...

Constitutive activation of the Wnt/β-catenin pathway promotes malignant proliferation and it is inversely correlated with the prognosis of patients with breast cancer. However, mutations in key regulators, such as APC, Axin and β-catenin, contribute to aberrant activation of the Wnt/β-catenin signaling pathway in various cancers, but rarely found in breast cancer, suggesting that other mechanis...

MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression. Genetic variation in miRNAs and miRNA-binding sites may affect miRNA function and contribute to disease risk. Here, we investigated the extent to which variants within miRNA-related sequences could constitute a part of the functional variants involved in developing Alzheimer's disease (AD), using the largest ava...

In 3 + 1 numerical simulations of dynamic black-hole spacetimes, it is useful to be able to find the apparent horizon(s) (AH) in each slice of a time evolution. A number of AH finders are available, but they often take many minutes to run, so they are too slow to be practically usable at each time step. Here I present a new AH finder, AHFINDERDIRECT, which is very fast and accurate: at typical ...

Serotonin Signaling in Pulmonary Hypertension Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2006 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.0000225927.04710.33 2006;98:1229-1231 Circ Res. http://circres.ahajournals.org/content/98/10/1229 World ...

Let M be a compact, hyperbolizable 3-manifold with nonempty incompressible boundary and let AH(π1(M)) denote the space of (conjugacy classes of) discrete faithful representations of π1(M) into PSL2(C). The components of the interior MP(π1(M)) of AH(π1(M)) (as a subset of the appropriate representation variety) are enumerated by the space A(M) of marked homeomorphism types of oriented, compact, ...

It is well known that the projection of a matrix A onto a Krylov subspace span { h, Ah, Ah, . . . , Ak−1h } results in a matrix of Hessenberg form. We show that the projection of the same matrix A onto an extended Krylov subspace, which is of the form span { A−krh, . . . , A−2h, A−1h,h, Ah, Ah . . . , A`h } , is a matrix of so-called extended Hessenberg form which can be characterized uniquely ...