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The Notch signaling pathway plays fundamental roles in diverse developmental processes. Studies of the basic biology of Notch function have provided insights into how its dysfunction contributes to multi-systemic diseases and cancer. In addition, our understanding of Notch signaling in maintaining stem/progenitor cell populations is revealing new avenues for rekindling regeneration. The Notch I...
2 Vilniaus universiteto ligoninės Santariškių klinikos, Radiologijos ir branduolinės medicinos centras Ektopinė kasa (EK) – reta įgimta anomalija, kai normalus kasos audinys yra už kasos ribų. Heterotopinis kasos audinys plonosios žarnos pasaite yra ypač retai sutinkamas EK tipas. EK dažniausiai aptinkama įvairiose virškinamojo trakto dalyse atsitiktinai. Paprastai EK yra simptomų nesukelianti ...
We examined the in vitro insulinotropic action of a novel non-sulfonylurea compound, calcium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinyl-carbonyl) propionate dihydrate (KAD-1229), which is a succinate derivative, using rat pancreatic islets and perfused pancreas. The sodium salt of KAD-1229 free acid (KAD-1229-Na) stimulated insulin secretion from isolated rat islets and perfused rat pancreas...
in the early 19th century and as a result of war circumstances, iran and britain experienced the formation and development of limited political intercourses. emergence of napoleon, as a serious danger made britain to pay a special attention to iran. on the other side, iran welcomed the expansion of its ties with britain due to its military conflicts with russia. although britain was not interes...
Proof. First suppose that a ∼H b, so that a = bk for some k ∈ H, and let ah (with h ∈ H) be an artibrary element of aH. Then we have ah = bkh = b(kh) ∈ bH, hence aH ⊆ bH. The proof of bH ⊆ aH is similar. Conversely, suppose that aH = bH. Since a ∈ aH = bH we have a = bk for some k ∈ H. Then a−1b = k−1 ∈ H, hence a ∼H b. (d) Prove that the map g 7→ ag is a bijection from H to aH. Proof. Consider...
Higher plant vasculature is characterized by two distinct developmental phases. Initially, a well-defined radial primary pattern is established. In eudicots, this is followed by secondary growth, which involves development of the cambium and is required for efficient water and nutrient transport and wood formation. Regulation of secondary growth involves several phytohormones, and cytokinins ha...
index (BMI, kg/m2) studies have been conducted in twins8, adoptees9, and family members10. The most convincing evidence that obesity is largely a genetic disease comes from studies of monozygotic twins reared apart. These studies are based on the assumption that when genetically identical individuals are separated at a young age and assigned randomly to different families, their shared environm...
Occupational noise-induced hearing loss (ONIHL) is a prevalent occupational disorder that impairs auditory function in workers exposed to prolonged noise. However, serum microRNA expression in ONIHL subjects has not yet been studied. We aimed to compare the serum microRNA expression profiles in male workers of ONIHL subjects and controls. MicroRNA microarray analysis revealed that four serum mi...
C57BLKS db/db (db/db) mice develop a neuropathy with features of human type 2 diabetic neuropathy. Here, we demonstrate that these mice develop transient mechanical allodynia at the early stage of diabetes. We hypothesized that nerve growth factor (NGF), which enhances the expression of key mediators of nociception (i.e. substance P [SP] and calcitonin gene<related peptide), contributes to the ...
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