BACKGROUND AND PURPOSE Circulating microRNAs (miRNAs) are emerging biomarkers for stroke because of their high stability in the bloodstream and association with pathophysiologic conditions. However, the circulating whole-genome miRNAs (miRNome) has not been characterized comprehensively in the acute phase of stroke. METHODS We profiled the circulating miRNome in mouse models of acute ischemic...

Die Urkunden der Markgrafen von Meißen und Landgrafen Thüringen, Bd. 5: 1248 – 1264, bearb. Tom Graber Mathias Kälble (Codex Diplomaticus Saxoniae I, Abt. A), Wiesbaden: Harrassowitz Verlag 2017. LXXVIII, 504 S. ISBN 978-3-447-10916-1. € 148,–

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1255 R I. REASONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1257 R II. RISKS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1261 R III. MEANS . . . . . . . . . . . . . . . . . ....

Single-chain antibodies neutralize activity and bind nonoverlapping epitopes of botulinum A neurotoxin. Two phage display epitope libraries were constructed from the 1.3 kb of binding domain cDNA. The minimal epitopes selected against the single-chain Fv-Fc antibodies correspond to conformational epitopes with amino acid residues 1115 to 1223 (S25), 1131 to 1264 (3D12), and 889 to 1294 (C25).

As required by the Routing Protocol Criteria [RFC 1264], this memo discusses the applicability of the Next Hop Resolution Protocol (NHRP) in routing of IP datagrams over Non-Broadcast Multiple Access (NBMA) networks, such as ATM, SMDS and X.25. 1. Protocol Documents The NHRP protocol description is defined in [1]. The NHRP MIB description is defined in [2].

CONTENTS Summary of key points and recommendations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1256 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1257 Capsaicin and citric acid inhalation cough challenge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1258 Cough induced by ...

anticancer drug that acts via inhibiting protein kinase C (PKC) and cyclin-dependent kinase 2 (CDK2). In pre-clinical studies, the compound exhibited potent anti-tumor effects both in vitro and in vivo. During clinical evaluation, the plasma concentrations of UCN-01 were much higher than predicted from non-clinical studies in experimental animals. The unexpectedly high plasma concentrations of ...