نتایج جستجو برای: 131 mibg
تعداد نتایج: 17316 فیلتر نتایج به سال:
در این تحقیق فرایند رادیو یددار شدن ترکیب متایدو بنزیل گوانیدین (MIBG) با ید-131 به روش جانشینی هستهدوستی در حضور آمونیم سولفات و کاتالیزگر مس (II) مورد بررسی قرار گرفته است. به منظور بهینهسازی فرایند، تأثیر پارامترهای مختلف بر بازده نشاندارسازی بررسی گردید. نتایج حاصل از آزمایشهای مختلف نشان داد که استفاده از حمام روغن با دمای C˚160 ضروری است. پس از اتمام فرایند نشاندارسازی، مرحله...
متا یدوبنزیل گوانیدین به عنوان هم فرمول ”نوراپینفرین“ با اتّصال به یُد رادیوآکتیو به صورت MIBG-I123 و MIBG-I131 به ترتیب برای تشخیص و درمان اختلالات غدّة فوق کلیوی، مانند فئوکروموسیتوما و نوروبلاستوما بکار رفته است. در این کار پژوهشی روشی سریع برای تولید MIBG-I131 عرضه شده است. متایدوبنزیل گوانیدین در مجاورت محلول سولفات مس به I131 اضافه و به مدّت 30 دقیق...
BACKGROUND Controversy persists as to the need for both MIBG and bone scanning in routine evaluation of neuroblastoma. AIM To compare the efficacy of I-131- metaiodobenzylguanidine (MIBG) scan against that of conventional Tc99m- methylene diphosphonate (MDP) bone scan for the detection of skeletal deposition of neuroblastoma. METHODS AND MATERIAL The study included 57 patients (36 boys, 21 ...
UNLABELLED (131)I-metaiodobenzylguanidine (MIBG) is specifically taken up in neuroblastoma, with a response rate of 20%-37% in relapsed disease. Nonradioactive carrier MIBG molecules inhibit uptake of (131)I-MIBG, theoretically resulting in less tumor radiation and increased risk of cardiovascular toxicity. Our aim was to establish the maximum tolerated dose of no-carrier-added (NCA) (131)I-MIB...
Objective(s): 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of 68Ga-DOTATATE PET/CT and 131I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of pa...
PURPOSE We retrospectively examined whether or not initial responses of first low-dose (131)I-meta-iodo-benzyl-guanidine radiotherapy ((131)I-MIBG therapy) in patients with malignant pheochromocytoma and paraganglioma had prognostic values. MATERIALS AND METHODS This study included 26 patients with malignant pheochromocytoma (n = 18) and paraganglioma (n = 8) who underwent the first (131)I-MI...
Nothing but NET: A review of norepinephrine transporter expression and efficacy of 131I-mIBG therapy
Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on imaging, yet the therapeutic response to (131) I-mIBG is only 30% in clinical trials, and off-targe...
a 38 years old male worker presented with an advanced left side retroperitoneal mass, with metastatic involvement of 11th thoracic vertebra (t11) and resultant paraparesia and paresthesia . the histopathologic examination and immunohistochemical analysis confirmed the diagnosis of paraganglioma. decompression laminectomy and fixation of involved vertebra resulted to considerable symptomatic rel...
Paragangliomas (PGLs) are rare neuroendocrine neoplasms of the autonomic nervous system dispersed from the skull base to the pelvic floor. We reported an extremely rare case with coexisting PGL of the retroperitoneum and urinary bladder. The patient complained of episodes of severe headache and palpitation during micturition, with a 1-year history of uncontrolled hypertension. The (131)I-metaio...
PURPOSE Iodine-131-metaiodobenzylguanidine ((131)I-MIBG) has been shown to be active against refractory neuroblastoma. The primary toxicity of (131)I-MIBG is myelosuppression, which might necessitate autologous hematopoietic stem-cell transplantation (AHSCT). The goal of this study was to determine risk factors for myelosuppression and the need for AHSCT after (131)I-MIBG treatment. PATIENTS ...
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