Mehdi Akhlaghi
Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Production and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
[ 2 ] - Development of Sm-153 chitosan for radiosynovectomy
Introduction: Developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. In this work, Sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. Methods: Sm-153 chloride was ob...
[ 3 ] - Experimental production and initial imaging of [18F]-14-Fluoro-6-thia-heptadecanoic acid ([18F]-FTHA) for myocardial performance [Persian]
Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier...
[ 4 ] - Diagnostic efficiency of 68Ga-DOTATATE PET/CT as compared to 99mTc-Octreotide SPECT/CT and conventional morphologic modalities in neuroendocrine tumors
Objective(s): In view of somatostatin receptor (SSR) expression on cell membranes of the majority of neuroendocrine tumors (NETs), functional imaging exploiting analogs of SSR alongside the anatomical imaging is the mainstay of this diagnostic modality. In this prospective study, we assessed and directly compared the diagnostic parameters of 68Ga-DOTATATE PET/CT and 99...
[ 5 ] - Manual production and quality control of 68Ga-PSMA-11 radiopharmaceutical for PET-CT imaging of prostate cancer: optimization and 60 production series experience
Background: 68Ga-PSMA-11, a novel PET radiopharmaceutical, is currently used for imaging of almost all prostate cancers. However, automatic radiolabeling procedures have been recommended. In this research, according to the chemical nature of the PSMA-11, manual, optimized and safe production of this radiopharmaceutical has been investigated and a standard method has been presented to achieve a ...
[ 6 ] - 68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors
Objective(s): 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of 68Ga-DOTATATE PET/CT and 131I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of pa...
[ 7 ] - Absorbed dose of Fetus in SPECT-CT Imaging of Mother's Abdomen Regions using Monte Carlo method
SPECT-CT is an imaging method for diagnosing diseases and studying physiology of the body. In this type of imaging, due to the use of radiopharmaceutical for imaging (SPECT) and X-rays (CT), a relatively high dose of radiation is introduced into the patient. If the patient is pregnant, considering that the developing fetus is sensitive to any radiation in the uterus throughout the entire period...
نویسندگان همکار