BACKGROUND Factor V Leiden has been described as a common genetic risk factor for venous thromboembolism. The geographic distribution of this abnormality varies greatly, being high in Europe and almost absent in Asia and Africa. Particularly high prevalence is observed in some Mediterranean countries, which suggests the Mediterranean origin of this mutation. Similarly, prevalence of silent muta...

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INTRODUCTION Nucleotide 1311 polymorphism at exon 11 of the glucose-6-phosphate dehydrogenase (G6PD) gene is fairly common in various populations worldwide, especially among Mediterranean populations. In this study, 1311 polymorphism in G6PD-deficient cases was identified by microarray technique. MATERIAL AND METHODS Four hundred and fifty clinically healthy subjects were screened and 32 case...

The physiological disposition of single intravenous injections of biologically active 131-labeled insulin of high specific activity containing an average of 0.8 atom of total iodine per molecule of insulin (mol wt 6000) and of biologically inactive 1311-insulin containing an average of 6 atoms of iodine per molecule were cc.mpared in the rat over a 3-hour interval at two dose levels: tracer or ...

Scanning of the radioactive tracers in the calvarium represents a major advance of diagnostic techniques in the evaluation of intracranial disease. The pioneering work by Moore (18) at Mayo Clinic in 1948 utilized 1311 labeled Di-lodo-fluorescein as the tracer detected by a Geiger-Muller tube. This now primitive system demonstrated a higher concentration of the isotope tracer in the brain tumor...