C-1311 is a small molecule, which has shown promise in a number of pre-clinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the ...

Effects of palmitic acid, inhibitors, uncouplers, and reduced and oxidized glutathione on the binding of insulin-131! and 131! to the isolated fresh or aged mitochondria were studied. The binding of insulin-1311 to the fresh mitochondria was unexpectedly increased to a greater degree with the exogenous addition of palmitic acid, glutathione, acetaldehyde and 2, 4-dinitrophenol to the medium. Th...

Imidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 ...

Tumour radioiodine concentration has been compared with serum thyroglobulin (Tg) and, in a few cases, with tumour complement of thyrotrophin receptors in patients with differentiated thyroid carcinoma. All tumours examined possessed TSH receptors. In most the complement was similar to that of normal thyroid tissue although all but one of the tumours had no detectable 1311 concentration in vivo ...

Increased urinary albumin excretion is not simply an aftermath of glomerular injury, but is also involved in the progression of diabetic nephropathy (DN).Whereas Toll-like receptors (TLRs) are incriminated in the renal inflammation of DN, whether and howalbumin is involved in the TLR-related renal inflammatory response remains to be clarified. Here, we showed that both TLR2 and TLR4, one of the...

The imidazoacridinone derivative C-1311 is an antitumor agent in Phase II clinical trials. The molecular mechanism of enzymatic oxidation of this compound in a peroxidase model system was reported earlier. The present studies were performed to elucidate the role of rat and human liver enzymes in metabolic transformations of this drug. C-1311 was incubated with different fractions of liver cells...

Genetic variation available for the improvement of fiber properties is restricted in commercial upland cotton (Gossypium hirsutum L.). Resources for fiber improvement exist in G. barbadense L., but introgression of traits has been a limited success. The objectives of this study were to investigate the genetic variation and heritability of agronomic and fiber traits within a diverse recombinant ...

5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor agent that is also active against autoimmune diseases. The intention of the present studies was to elucidate the role of selected liver enzymes in metabolism of C-1311 and the less active 8-methyl derivative, 5-diethylaminoethylamino-8-methoxyimidazoacridinone (C-1330). Compounds were incubated with rat liver microsoma...

The use of thyroid preparations to reduce the size of non-toxic goitres is well established, as is their use in differentiating between high 1311 uptake rates due to thyrotoxicosis and those occurring in non-toxic goitres (Greer and Smith, 1954; Werner and Spooner, 1955). It would seem reasonable to expect that the amount by which the thyroidal 1311 uptake can be suppressed by thyroid preparati...