para-aminobenzoic acid is supported on silica gel via reaction of activated silica gel and p-aminobenzoic acid which is then converted to its manganese and cobalt salts. a mixture of the manganese and cobalt salts of the acid is used to catalyze allylic and benzylic alcohols to their corresponding carbonyl compounds in reasonable yields using oxygen or air. reactions are clean and the catalysts...

The bacteriostatic action of 2-chloro-4-aminobenzoic acid (2-Cl-PAB) was found by Wyss, Rubin, and Strandskov (1943) to be completely reversed by p-aminobenzoic acid. This, according to the theory of Woods (1940) that p-aminobenzoic acid is a specific antagonist for sulfanilamide, classified the bacteriostatic action of 2-Cl-PAB as sulfonamide activity. The bacteriostatic action of this compoun...

Since the eshablishment of p-aminobenzoic acid as a member of the B vitamin group, a considerable interest has been shown in methods of determination in natural materials. Since known chemical methods are not sufficiently sensitive, it became evident that microbiological tests should be the most practicable. The organism Clostridium acetobutylicum has been used (I) but no general assay procedur...

It is now well established that para-aminobenzoic acid inhibits the action of sulfonamides on bacteria in vitro and in vivo .(Rubbo and Gillespie, 1940; Selbie, 1940; Woods, 1940). Wiedling (1941) found that para-aminobenzoic acid produced an inhibition of the effect of sulfanilamide, sulfapyridine and sulfathiazole on the fresh water diatom Nitzschia palea var. debilis. Experiments published b...

The realization that p-aminobenzoic acid is essential as a growth factor has stimulated extensive research in the field of antagonists of this essential metabolite. Woods (1940) and Woods and Fildes (1940) reported that yeast contained a substance, identified as p-aminobenzoic acid, that could protect it against the growth inhibiting action of sulfanilamide. Youmans et al. (1947) reported the t...

The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...

The adsorption behavior of p-aminobenzoic acid and o-aminobenzoic acid onto the different polymeric adsorbents was systematically investigated as a function of the solution concentration and temperature. Experimental results indicated that the equilibrium adsorption data of the four polymeric adsorbents fitted well in the Freundlich isotherm. The adsorption capacity of multi-functional polymeri...

The formation of folic acid compounds from pteridines and p-aminobenzoic acid by whole bacterial cells has been studied by Korte et al. (1, 2), who reported that C%xanthopterin (2-amino4,6-dihydroxypteridine) could be incorporated into folic acid by several bacterial species, and by Weygand et al. (3), who found that certain strains of bacteria can be adapted to utilize 2.amino-4-hydroxy-6-form...

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

Objective(s):Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. Materials and Methods: In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...