the present study was conducted to test the effect of origanum majoranum extract (ome) of leaves on alterations induced in a model of type 2 diabetic rats. adult male wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. diabetic rats were given aqueous extract of ome in a dose of 20 mg/kg orally ...

background and objectives: cyclooxygenese-2 (cox-2) expression in breast cancer and its correlation with tumor prognosis is unclear. we investigated the incidence of cox-2 expression in patients and assessed interactions between cox-2 and clinical features of cancer and expression of her2/neu, estrogen receptor (er), and progesterone receptor (pr). methods: cox-2 expression was investigated by...

background: lymphomas are a group of malignancies affecting b, t and nk cells. cox-2 enzyme is one of the known inflammatory factors which increase in the inflammation process. increase in cox-2 expression inhibits apoptosis and increases tumor cells invasion and angiogenesis. increase in the cox-2 gene expression is seen in a group of cancers .specific cox-2 inhibition also can be beneficial i...

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

Background and Objectives: Cyclooxygenese-2 (COX-2) expression in breast cancer and its correlation with tumor prognosis is unclear. We investigated the incidence of COX-2 expression in patients and assessed interactions between COX-2 and clinical features of cancer and expression of HER2/neu, estrogen receptor (ER), and progesterone receptor (PR). Methods: COX-2 expression was investigated by...

background and objective: egfr and her-2 are two members of erbb/her family of type i transmembrane growth factor receptors. cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. the aim of this study was to determine the level of expression of egfr, her-2 and cox2 in colorectd cancer. mater...