The effects of cytosol, NADPH and reduced glutathione (GSH) on the activity of 5'-deiodinase were studied by using washed hepatic microsomes from normal fed rats. Cytosol alone had little stimulatory effect on the activation of microsomal 5'-deiodinase. NADPH had no stimulatory effect on the microsomal 5'-deiodinase unless cytosol was added. 5'-deiodinase activity was greatly enhanced by the si...

هدف: پژوهش حاضر با هدف بررسی مقایسه اثربخشی گروه درمانی شناختی – رفتاری و ذهن ­آگاهی مبتنی بر شناخت کاهش رفتارهای پرخطر در معتادان ترک افیونی صورت گرفت. روش: روش این شبه آزمایشی طرح پیش آزمون پس همراه کنترل است. جامعه­ی آماری شامل کلیه افراد وابسته به مواد مراجعه کننده مرکز اعتیاد شبکه بهداشت درمان شهرستان سرپل ذهاب نیمه اول سال 1396 بود، نمونه­ گیری دسترس تعداد 36 نفر تشخیص وابستگی اساس معیاره...

Reactive oxygen intermediates (ROI) play an important role in cell signaling in addition to their role in microbial killing. We have shown previously that exogenous ROI regulate activity of the enzyme 5-lipoxygenase (5-LO) in alveolar macrophages (AM). Here, we examined the role of endogenous ROI, specifically generated by NADPH oxidase, in the regulation of leukotriene (LT) synthetic capacity ...

accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...