Cortical lamination is crucial for the assembly of cerebellar circuitry. In this process, granule neurons (GNs) migrate along Bergmann glia (BG), which are specialized astroglial cells, from the external granule layer to the internal granule layer. However, the molecular mechanisms underlying BG development are not well understood. Here, we show that GFAP::Cre;Erbb3 mice, which lack Erbb3 in bo...

Non-small cell lung cancer (NSCLC), one of the most common causes of cancer-related death, is a worldwide public health problem. MicroRNAs (miRNAs) have recently been identified as a novel class of regulators of carcinogenesis and tumor progression, including miRNAs associated with NSCLC. This study aimed to explore the role of miR-522 in NSCLC and the mechanisms underlying this role. We report...

Shape oen has a decisive inuence over the properties and applications of monodisperse nanoparticles. In addition, size is another important factor controlling the properties of the nanomaterials owing to various connement effects. Therefore, the synthesis of diverse, high-quality nanoparticles with tunable shapes and sizes has become a challenging issue and drawn considerable attention. Morp...

How do we know that claims made by software How do we know that claims made by software engineers are true? engineers are true? Do computer scientists understand the scientific Do computer scientists understand the scientific process? process? process? process? How do we compare tools, processes, techniques? How do we compare tools, processes, techniques? Introduction Introduction " One " One o...

Course Description: The goal of this course is to expose students to advances topics in classical electromagnetism with a contemporary point of view. Broadly, three areas will be considered: Electromagnetic sources, propagation of electromagnetic radiation, and the interaction of electromagnetic radiation with materials. Specific topics include antennas, Lienard-Wiechert potentials, synchrotron...

Gordona terrae strain C-6 was isolated from oil-contaminated soil and is capable of desulfurizing benzothiophene (BT). Here we report the draft genome sequence of G. terrae strain C-6, which may help to reveal the genetic basis of the BT biodesulfurization pathway.

MicroRNAs (miRNAs) are small non-coding RNAs, which are important in the development of multidrug resistance in cancer by regulating gene expression at the post‑transcriptional level. The present study investigated the functional effects of miR‑522 in chemoresistant colon cancer cells. The results demonstrated that miR‑522 was significantly downregulated in doxorubicin (DOX) resistant colon cel...

Selective cyclooxygenase-2 (COX-2) inhibitors have been demonstrated to inhibit the proliferation of a variety of cancer cells including hepatocellular carcinoma (HCC). We sought to explore the mechanisms by which JTE-522, a selective COX-2 inhibitor, suppressed the growth of human HCC cells. HCC cells (HepG2, HLF, huH1, Huh7, and PLC/PRF/5 cells) did not express COX-2 at either the mRNA or pro...

The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse neuropsychiatric effects. Selective blockade of peripheral CB1Rs has the potential to provide a viable strategy for the treatment of severe obesity while avoiding these central nervous system side effects. In the current study, a novel compound (TX...