Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers. We systematically characterized miRNA expression and editing in the human brain, which displays the highest number of A-to-I RNA editing sites among human tissues, and in de novo glioblastoma brain cancer. We identified 299 miRNAs altered in their expression and 24 miRNAs differently edited in human brain com...

32.1 Smoothed ANOVA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 586 32.1.1 Zhang et al.’s SANOVA proposal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 586 32.1.2 Maŕi-Dell’Olmo et al.’s SANOVA proposal . . . . . . . . . . . . . . . . . . . . . . . . . . . 588 32.2 Some Specific Application...

Katja Suhonen Tampere University of Technology, Human-Centered Technology, P.O.Box 589, 33101 Tampere, Finland [email protected] Kaisa Väänänen-Vainio-Mattila Tampere University of Technology, Human-Centered Technology, P.O.Box 589, 33101 Tampere, Finland [email protected] Kalle Mäkelä Tampere University of Technology, Department of Electronics, P.O.Box 692, 33101 Tampere, ...

We present new optical spectral observations of 3G71, the previously suspected optical counterpart of the hard X-ray source 1H2214+589. The spectra of 3G71 exhibit many forbidden lines, unusually intense H-Balmer emission lines and the approximately B5 spectral type. Such spectral features, together with its large IRAS infrared color excess and associated with nebulosity, provide evidences that...

Although many long non-coding RNAs (lncRNAs) have been discovered, their function and their association with RNAi factors in the nucleus have remained obscure. Here, we identify RNA transcripts that overlap the cyclooxygenase-2 (COX-2) promoter and contain two adjacent binding sites for an endogenous miRNA, miR-589. We find that miR-589 binds the promoter RNA and activates COX-2 transcription. ...

We describe a 5.5W 589 nm source based on a passively mode-locked Nd:YVO4 laser and a multi-stage Lithium Triborate optical parametric amplifier seeded by a tuneable semiconductor laser. We show this system can produce rapidly tuneable, transform-limited pulses in near diffraction-limited beams at 589 nm, useful for Na guide star applications. The attraction of this scheme is that it can be ass...

Introduction .................................................................................................................................... 583 Background .................................................................................................................................... 584 Gene Therapy for Temporal Lobe Epilepsy ..............................................................

The experimental vibrational circular dichroism, electronic circular dichroism, and optical rotatory dispersion spectra and corresponding quantum chemical predictions of 3,3'-diphenyl-[2,2'-binaphthalene]-1,1'-diol (VANOL) are used to confirm its absolute configuration as (+)(589)-(aR) or (-)(589)-(aS). A discrepancy in the literature crystal structure has been resolved by determining the X-ray...