نتایج جستجو برای: 589

تعداد نتایج: 1946  

2000
Stuart A. Lockwood Eugenio D. Beltrán-Aguilar

Journal: :Pediatric Critical Care Medicine 2018

2015
Aditya Sen Sreehari Kalvakuri Rolf Bodmer Rachel T. Cox

Loss of mitochondrial function often leads to neurodegeneration and is thought to be one of the underlying causes of neurodegenerative diseases such as Parkinson’s disease (PD). However, the precise events linking mitochondrial dysfunction to neuronal death remain elusive. PTEN-induced putative kinase 1 (PINK1) and Parkin (Park), either of which, when mutated, are responsible for early-onset PD...

2015
Xiaoliang Zhuo Xiaohua Stella Huang Andrew P. Degnan Lawrence B. Snyder Fukang Yang Hong Huang Yue-Zhong Shu Benjamin M. Johnson

A recent medicinal chemistry campaign to identify positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) led to the discovery of potent compounds featuring an oxazolidinone structural core flanked by biaryl acetylene and haloaryl moieties. However, biotransformation studies of some of these mGluR5 PAMs demonstrated the formation of glutathione (GSH) conjugat...

2016
Xi Zhang Peng Jiang Ling Shuai Kai Chen Zhonghu Li Yujun Zhang Yan Jiang Xiaowu Li

BACKGROUND Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC. METHODS The miRNA profiles of CD90+ and CD90- HCC cells were analyzed using a miRNA microarray and quantitative real-time PCR (...

Journal: :Genetics 2003
J W Mavor H K Svenson

PAGE INTRODUC~ON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 588 Description of experiments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 589 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Journal: :World Allergy Organization Journal 2012

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