Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

OBJECTIVES To evaluate the effectiveness and acceptability of a lidocaine spray in reducing perineal pain during spontaneous vaginal delivery. DESIGN Randomised controlled trial. SETTING Consultant led obstetric unit. PARTICIPANTS 185 women who had a spontaneous vaginal delivery without epidural analgesia. INTERVENTIONS Topically applied local anaesthetic spray (93 women) and placebo sp...

background: lidocaine is a local anesthetic and antiarrhythmic agent. there are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

background and purpose: suitable sedation during gastrointestinal (gi) tract endoscopy leads to the patient’s and the physician’s satisfaction and enhances the quality and the adequacy of the procedure. materials and methods: in a clinical trial, 140 patients were randomly assigned into two groups in order to compare the adequacy of upper gi tract endoscopy after choosing the type of sedation b...

OBJECTIVE To investigate the efficacy and safety of lidocaine nasal spray before nasogastric tube insertion in an emergency department. DESIGN Double-blind, randomised controlled study. SETTING Emergency department of a major regional hospital in Hong Kong. PATIENTS A total of 206 adult patients, for whom nasogastric tube insertion was indicated. MAIN OUTCOME MEASURES Primary outcome wa...

Transdermal Delivery System (TDS) is a liquid formulation which can be applied to the skin via a metered pump spray to deliver drug across skin. This placebo controlled, double blind trial compared anaesthetic properties of two TDS systems (TDS alpha and TDS beta) with placebo. The active and placebo treatments were applied to the dorsum of the hands, bilaterally and simultaneously for 5 min on...

OBJECTIVES To identify the optimal pharmacological method of preparing patients for nasal endoscopy. METHODS Twenty healthy volunteers were enrolled in this prospective, randomized, double-blind study. Four types of medications were applied in their nostrils with binary combinations of spray bottles on four different days in a random order: placebo (normal saline [NS]+NS), decongestant (NS+ox...