This summary is intended to update the Brazilian Society of Bone Marrow Transplantation and Cellular Therapy (SBTMO) 2020/1 consensus on HSCT for Acute Myeloid leukemia (AML).

Background and Aims: DNA methyltransferase3A (DNMT3A) is necessary for the adjustment of gene expression, and the mutations in the DNMT3A gene are reported in a variety of leukemia cases. DNMT3A mutations are during cancer progression and cause poor prognosis in many leukemias. Thus, this gene can be a target for new treatments. This study aimed to examine the distribution of DNMT3A mutations i...

Acute myeloid leukemia (AML) is a disease characterized by neoplastic transformation and abnormality of progenitor cells differentiation from cells. In AML there heterogeneous in hematopoietic cells, this has been identified affects the balance between proliferation, survival body Mutation FMS-like tyrosin kinase 3 (FLT3) gene causes overexpression which one most often found mechanism that coul...

Myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (AML). The tumor mass may precede or occur concurrently with AML, CML, myeloproliferative disorders, and/or myelodysplastic syndromes. Histologically, it looks like a large cell lymphoma and can be misdiagnosed. A case refe...

Tiny non-coding RNAs called microRNAs (miRNAs) are crucial for cell survival and differentiation. Numerous cancer varieties, including acute myeloid leukemia, have been linked to abnormal miRNA expression (AML). Objective:

Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia.    Methods: In this case-control study, peripheral blood samples from 100 AML and 10...

the significance of immunophenotyping is growing day by day. it provides basic information in regard to classification and prognosis of acute leukemia which helps the management of patients. this study was conducted to identify cd markers in leukemic patients admitted to tabriz, in northwestern iran. immunophenotyping of 60 patients with acute leukemia was determined. patients with acute myelog...

Abstract Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment AML which target BCL-2 or membrane receptor CD38. Here, we show that with Venetoclax and Daratumumab combination resulted slower tumor progression reduced growth both vitro vivo. These data provide evidence clinical evaluat...

Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have d...