objectives: curcumin has anti-inflammatory and antioxidative properties. the objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (i/r). materials and methods: animals were randomly divided into 9 groups. the groups with 24-h reperfusion consisted of sham-24h,...

the aim of this study is to investigate antioxidant enzymes, oxidative stress biomarkers and the acute phase proteins levels for subclinical and clinical pregnancy toxemia and to determine the effect of early diagnosis on the success of curing. according to the results of clinical and biochemical parameters, from 39 ewes, 10 were healthy ewes (control group), 13 ewes had subclinical pregnancy t...

background. the major side effect of cisplatin, used in some tumours, is nephrotoxicity. reactive oxygen species and oxidative damage are the most important factors in cisplatin-induced acute renal failure. the main purpose of this study is to investigate the protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rat. methods. in this study, animals w...

Introduction: Stress is a main factor influencing brain functions as revealed by the electroencephalogram (EEG) recordings. Moreover, different stress durations seemingly cause perturbations in brain waves and lead to mental disorders. This study investigates the effects of acute, sub-chronic and chronic stress on EEG in rats.  Methods: Twenty-eight Wistar adult male rats were randomly all...

introduction: in this study, the effect of memantine administration into the nucleus accumbens on the metabolic changes induced by acute stress in female mice was evaluated. methods: intra-accumbens unilateral or bilateral canulation was performed. one week after recovery, a group of animals were given memantine (1, 0.5, and 0.1 μg/mouse) five min before stress induction intra-accumbally, and t...

background: brucella species can cause infection in a wide range of animals and human beings. oxidative events against brucella infection are not well elucidated. it is possible that brucellosis may be related to increased free radical production and antioxidant depletion. thus, the aim of this study was to determine the total antioxidant capacity (tac) before and after treatment of patients wi...

Introduction: As stress affects the brain both physiologically and chemically, researchers try to find novel anti-stress compounds with beneficial therapeutic effects. In this regard, the effect of stress and its modulation by Morin hydrate was studied using different acute models in mice. Methods: The models employed were anoxic tolerance, swimming endurance, and acute restraint test. Morin h...

background: renal ischemia reperfusion (ir), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. the aim of this study was to investigate the effects of hydroxytyrosol (ht) on renal ischemia-reperfusion injury in mice. methods: male mice were randomly assigned to three groups (n = 9): (1) sham operated, (2...