نتایج جستجو برای: acute toxicity tests

تعداد نتایج: 914815  

Objective(s): Nanomaterials, especially silver Nanoparticles (Ag-NPs), are employed in an increasing number of commercial products. This has led to an ever growing exposure of human beings to this substance. The first purpose of the Nano Committee of Food and Drug Administration of The Islamic Republic of Iran (IFDA) is developing guidelines to assess and approve commerci...

Journal: :iranian journal of pharmaceutical research 0
h yazdanpanah l hosseinzadeh n bazmohammadi m kamalinejad

teucrium polium l. (tp) is widely used in traditional medicine of many countries including iran. there are various reports about pharmacological properties of tp such as calcium antagonist, anti- ulcer, anti – diabetic. there are a few reports about possible toxicological effects of this plant. in the present study we designed to evaluate the subchronic toxicity of teucrium polium total extract...

Journal: :iranian journal of basic medical sciences 0
hamid reza rasekh school of pharmacy, shahid beheshti university of medical sciences, tehran, iran leila hosseinzadeh school of pharmacy, kermanshah university of medical sciences, kermanshah, iran soghra mehri school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad kamli-nejad school of pharmacy, shahid beheshti university of medical sciences, tehran, iran majid aslani school of pharmacy, shahid beheshti university of medical sciences, tehran, iran farahnaz tanbakoosazan school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

objective(s) ocimum basilicum l. is widely used in folk medicine of many countries including iran. both o. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. therefore, in the present study, acute and subchronic toxicity of o. basilicum hydroalcohlic extract have been eva...

Journal: :Toxicology in vitro : an international journal published in association with BIBRA 2017
Jon Hamm Kristie Sullivan Amy J Clippinger Judy Strickland Shannon Bell Barun Bhhatarai Bas Blaauboer Warren Casey David Dorman Anna Forsby Natàlia Garcia-Reyero Sean Gehen Rabea Graepel Jon Hotchkiss Anna Lowit Joanna Matheson Elissa Reaves Louis Scarano Catherine Sprankle Jay Tunkel Dan Wilson Menghang Xia Hao Zhu David Allen

Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-...

Journal: :Alternatives to laboratory animals : ATLA 2010
Martin Vaughan Roger van Egmond

At present, the acute toxicity of chemicals to fish is most commonly estimated by means of a short-term test on juvenile or adult animals (OECD TG 203). Although, over the last few years, the numbers used have been reduced due to the implementation of the Three Rs (Reduction, Refinement and Replacement), significant numbers of fish are still used in acute toxicity tests. With the introduction o...

Journal: :Environmental toxicology and chemistry 2012
Gabriel S Weyman Hans Rufli Lennart Weltje Edward R Salinas Marc Hamitou

Aquatic toxicity tests with substances that are poorly soluble in water have been conducted using different methods, and estimates of toxicity have varied accordingly. The present study illustrates differences in toxicity values resulting from variation in test designs and solution preparation methods, and offers guidance on the best way to conduct these tests. Consequences for environmental ri...

ژورنال: کومش 2021

Introduction: In Iranian traditional medicine, Asparagus persicus has been used for treating rheumatic pain and inflammation. The aim of this study was to evaluate the analgesic and anti-inflammatory as well as acute toxicity effects of Asparagus persicus root essential oil (APEO) in male mice. Materials and Methods: Male adult mice were used. In pain assessment tests (writhing, tail-flick, and...

Journal: :jundishapur journal of natural pharmaceutical products 0
mansor amin department of microbiology, school of medicine, infection and tropical diseases research center, ahvaz jundishapur university of medical sciences, ir iran mohammad hassan hassan pipelzadeh department of pharmacology and toxicology research centre, ahvaz jundishapur university of medical sciences, ir iran +98-6114458849, [email protected]; department of pharmacology and toxicology research centre, ahvaz jundishapur university of medical sciences, ir iran +98-6114458849, [email protected] manijeh mehdinejad department of microbiology, school of medicine, infection and tropical diseases research center, ahvaz jundishapur university of medical sciences, ir iran iran rashidi department of pathology, school of medicine, ahvaz jundishapur university of medical sciences, ir iran

background previous studies have shown that shallomin, one of the active constituents of persian shallot, has a broad range of antimicrobial properties. objectives the safety of shallomin must be established before it can be used in clinical applications. therefore, the aim of the present study was to evaluate the acute toxic effects of shallomin and to estimate its lethal dose low (ldlo) value...

Journal: :Environmental Health Perspectives 1998
E Walum

The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. The LD50 value, defined as the statistically derived dose that, wh...

Journal: :international journal of environmental research 0
s. tong school of forestry and bio-technology, zhejiang forestry college, lin-an 311300, people’s republic of china s. tong school of forestry and bio-technology, zhejiang forestry college, lin-an 311300, people’s republic of china p. wang school of forestry and bio-technology, zhejiang forestry college, lin-an 311300, people’s republic of china j. chen college of biological and environmental engineering, zhejiang university of technology, hangzhou 310032, people’s republic of china

the toxicity of 7 herbicides to the three cyanobacteria was tested in this work. the results indicated that: (1) there was a highly significant relationship between dried weight or chlorophyll-a and od680nm for tested cyanobacteria; (2) the toxicity of the tested herbicides with the order from high to low was: photosynthesis-inhibiting > accase inhibitor > protox inhibiting herbicides; (3) the ...

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