نتایج جستجو برای: adad
تعداد نتایج: 72 فیلتر نتایج به سال:
It has been hypothesized that the relatively rare autosomal dominant Alzheimer disease (ADAD) may be a useful model of the more frequent, sporadic, late-onset AD (LOAD). Individuals with ADAD have a predictable age at onset and the biomarker profile of ADAD participants in the preclinical stage may be used to predict disease progression and clinical onset. However, the extent to which the patho...
The autosomal dominant form of Alzheimer's disease (ADAD) is far less prevalent than late onset Alzheimer's disease (LOAD), but enables well-informed prospective studies, since symptom onset is near certain and age of onset is predictable. Our aim was to discover plasma proteins associated with early AD pathology by investigating plasma protein changes at the asymptomatic and symptomatic stages...
PSEN1 mutations are the most frequent cause of autosomal dominant Alzheimer's disease (ADAD), and show nearly full penetrance. There is presently increasing interest in the study of biomarkers that track disease progression in order to test therapeutic interventions in ADAD. We used white mater (WM) volumetric characteristics and diffusion tensor imaging (DTI) metrics to investigate correlation...
BACKGROUND Autosomal dominant familial Alzheimer's disease (ADAD) is a rare disorder with non-amnestic neurological symptoms in some clinical presentations. We aimed to compile and compare data from symptomatic participants in the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) with those reported in the literature to estimate the prevalences of non-amnestic neurological s...
The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Inosine can have a profound effect on the RNAs that are edited, not only changing the base-pairing properties, but can also result in recoding, as inosine behaves as if it were guanosine. In mammals there are three ADAR proteins and two ADAR-related p...
Dominantly Inherited Alzheimer Network; and et al, ,"Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer's disease: Results of the DIAN study. Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alz...
Background Metabolic dysregulation has been implicated in the pathobiology of Alzheimer’s disease (AD), including familial autosomal dominant AD (ADAD). Recent metabolic neuroimaging preclinical ADAD mutation carriers suggested that levels reactive glial marker myo-inositol increase with proximity to expected age at dementia onset. It remains unclear, however, if similar change related anticipa...
Coronavirus disease 2019 (COVID-19) generated a global public health emergency since December 2019, causing huge economic losses. To help radiologists strengthen their recognition of COVID-19 cases, we developed computer-aided diagnosis system based on deep learning to automatically classify chest computed tomography-based COVID-19, Tuberculosis, and healthy control subjects. Our novel classifi...
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