نتایج جستجو برای: adenosine receptors
تعداد نتایج: 307548 فیلتر نتایج به سال:
Introduction:Adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rCBF). Metod: Laser-Dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. Male Sprague Dawley rats (250-350g) that were housed in standard conditions, were anesthetized with Urethane (1.5g/kg). Adenosine ...
Introduction & Objective: In the CNS, adenosine is known to suppress repetitive neuronal Firing, suggesting a role as an endogenous modifier of seizures. Indeed, intracerebral adenosine concentrations rise acutely during seizure activity and are thought to be responsible for terminating seizures and establishing a period of post-ictal refractoriness. However, it is unclear whether this suppre...
In this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (PGi) neurons was investigated. The spontaneous activity of PGi neurons was significantly decreased by microinjection of adenosine (10 nM, 0.5 µl) into PGi nucleus of both control and morphine-dependent rats. The decrease in firing rate of PGi neurons of morphine-dependent rats was greater than t...
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning memory, motor function, feeding, control of sleep aging. Adenosine is involved stroke, epilepsy neurodegenerative pathologies. Extracellular concentration the brain t...
epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. it has been shown that each seizure has a depressing effect on the following seizure. thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. in this study, the role of adenosine a1 receptors in pos...
in this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (pgi) neurons was investigated. the spontaneous activity of pgi neurons was significantly decreased by microinjection of adenosine (10 nm, 0.5 µl) into pgi nucleus of both control and morphine-dependent rats. the decrease in firing rate of pgi neurons of morphine-dependent rats was greater than t...
There are several reports that adenosine and carbamazepine have pharmacodynamic interaction. I n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. Agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially showed antinociceptive effects. Carbamazepine had antinociceptive acti...
Introduction: Damage to the central and peripheral nervous system causes neuropathic pain. Caffeine is a plant alkaloid and non-selective antagonist of A1, A2a and A2b adenosine receptors. It is reported that caffeine increases the threshold of pain. In this study, the effect of acute caffeine on behavioral responses of neuropathic pain was investigated. Materials and Methods: The present study...
introduction: the role of adenosine a1 receptors of the entorhinal cortex on amygdaloid kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimulation of amygdala. in the full kindled animals, n6-cyclohexyladenosine (cha; 0.1, 1 and 10 mm), an adenosine a1 receptor agonist, and 8-cyclopenthyle 1,3-dimethylexanthine (cpt), an adenosine a1 receptor a...
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