background: the relationships between adiponectin and clinical outcomes in hemodialysis (hd) patients remain highly controversial. meanwhile, the association between adiponectin and the peripheral artery disease (pad) has not been well studied in hd patients without diabetic mellitus. materials and methods: the ankle-brachial index was measured in hd patients. adiponectin levels in 105 hd patie...

The importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized. Adiponectin has a central role in regulating glucose and lipid metabolism and controlling inflammation in insulin-sensitive tissues and low adiponectin levels have been linked to NAFLD. APPL1 and APPL2 are adaptor proteins that interact with the in...

adipose tissue secretes a large number of adipocytokines such as leptin, resistin, and adiponectin. many of these hormones and cytokines are altered in obese individuals and may lead to disruption of the normal balance between cell proliferation, differentiation, and apoptosis. the aim of our work was to investigate the disturbance of secretion of adiponectin and resistin in de novo and relapse...

conclusions it is speculated that increased insulin resistance and increase in other adipokines such as il-6 may contribute to the decreased serum levels of adiponectin in patients with both cad and t2dm. objectives in this present study, we measured serum adiponectin levels in consecutive cad patients with and without t2dm and investigated whether decreased adiponectin is associated with risk ...

in view of the fundamental role of genetics in development of obesity, the present study aimed to investigate the single nucleotide polymorphism of some obesity-related genes among a subset of obese women living in tabriz, iran. for this purpose, 70 eligible obese women (aged 18-45 years) were genotyped for the uncoupling protein-1 (ucp-1) -3826a>g, ß3-adrenergic receptor (ß3adr) trp64arg, lept...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

Prostate cancer (PCa) is the most common type of cancer among men over 60 years old. The aggressiveness and mortality of PCa can be correlated with obesity. Adipose tissue-derived cytokines such as adiponectin may explain the correlation between PCa and obesity. Since the correlation between adiponectin and aggressive PCa is still not fully evaluated, we aimed to investigate the probable role o...

background: the existing evidence suggests that plasma adiponectin concentrations can be indicative of the presence and severity of coronary artery disease (cad). however, the results of the studies conducted hitherto on this subject are inconsistent. we sought to investigate the possible correlation between plasma adiponectin levels and the presence and severity of cad in patients undergoing n...