Background:  Maternal sleep deprivation is known to reduce neurogenesis in the hippocampus during pregnancy. Also, it damages and impairs cognitive functions such as learning and memory in the neonates.  Objectives: Rosmarinus officinalis (rosemary) extract can play an important role in the treatment of cognitive impairments by inhibiting oxidative stress. This study aimed to investigate the r...

OBJECTIVE The circadian secretory profiles of cortisol and growth hormone (hGH) in normal subjects are interrelated. Slight alterations in cortisol secretion are paralleled by similar ones of hGH secretion. Under physiological conditions an inhibitory effect of glucocorticoids on hGH secretion is more potent than a stimulatory one, while in normal young subjects the nychtohemeral cortisol and h...

The effects of sleep deprivation were studied on the occurrence of spike-wave discharges in the electroencephalogram of rats of the epileptic WAG/Rij strain, a model for absence epilepsy. This was done before, during and after a period of 12 hours of near total sleep deprivation. A substantial increase in the number of spike-wave discharges was found during the first 4 hours of the deprivation ...

AIM To examine the effect of acute sleep deprivation under light conditions on the expression of two key clock genes, hPer2 and hBmal1, in peripheral blood mononuclear cells (PBMC) and on plasma melatonin and cortisol levels. METHODS Blood samples were drawn from 6 healthy individuals at 4-hour intervals for three consecutive nights, including a night of total sleep deprivation (second night)...

STUDY OBJECTIVES To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means of corticosterone inhibition with metyrapone. DESIGN The design was a 2 (Groups [control, paradoxical sleep-deprived]) x 2 (Treatments [vehicle, metyrapone]) study, performed in 2 experiments: Acute treatment (single injection given immediately after 96...

STUDY OBJECTIVES Sleep deprivation is believed to worsen obstructive sleep apnea (OSA). We assessed the effect of acute sleep deprivation on polysomnography in a cohort of subjects with mild OSA and a cohort of subjects without OSA. DESIGN Crossover study in which subjects initially had polysomnography after a normal night's sleep or after 36 hours of sleep deprivation, followed by a 2- to 4-...

It is a common belief that sleep deprivation increases the susceptibility to diseases. In order to evaluate the effects of sleep deprivation on immune profile in humans, peripheral venous blood was obtained from sixteen healthy young male volunteers. Ten of the volunteers underwent 48 hours of sleep deprivation and the other six maintained their regular sleep schedule and acted as controls. The...

According to a survey conducted in 2007, 35-40% of adult U.S population chronically restricts their sleep on less than 7 hours on weekday nights, compared with 8-9 hours to maintain brain normal function during the day. Studies have demonstrated that sleep deprivation reduces the capabilities and efficiency of performance by impairing perception, increasing effort to keep concentrate, as well a...

Fatigue is a recognised problem in the transport industry. It has been attributed to two main influences: time of day and the time since last sleep. While the role of these two influences in producing fatigue is not disputed, there is less agreement on how they interact with one another. The aim of this study was to examine the relative effects of time of day and sleep deprivation on fatigue an...