intraperitoneal (ip) injection of bupropion (3,6, amine (4,16 mg kg•&apos;) induced dose-dependent climbing in mice. the climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist sch 233<)0 or the 0-2 antagonist sulpiride. the α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adre...

administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. in the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p

Introduction Anti-arrhythmic drug therapy carries an understood risk for toxic side effects, even at therapeutic doses. In cases of high dose ingestion these toxic effects can present rapidly with extra-cardiac symptoms, malignant arrhythmias and lifethreatening hemodynamic deterioration. Prescribing clinicians should maintain familiarity with the mechanisms and kinetics of the anti-arrhythmic ...

conclusions the findings of the study showed that, compared with the opiate users, methamphetamine users are younger, more likely to be single, and less likely to have received treatment. we recommend that policymakers should not only design preventive programs for improving the level of knowledge about stimulant use, but also prepare treatment plans and facilities for this newly emerged substa...

  There is evidence indicating that adrenoceptor mechanisms may influence some of the behaviors in rat. However the role of adrenoceptor agents on sniffing has not been identified. In the present study, the influence of adrenoceptor agents on sniffing induced by apomorphine and amphetamine has been investigated. Male Albino rats, weighing 150-250 g were used for all experiments. The behavior wa...

conclusions performing htp can improve hopefulness and symptoms of patients, specially addicted ones. in addition, it can prevent substance abusers from returning to drugs and leaving the treatment period unfinished. results the results showed that f value of mean scores in depression and hope post-tests of the experimental and control groups are 24.94 and 25.73, respectively, which are signifi...

AIM Amphetamine and its derivates can induce, usually after many intoxications, schizophrenia-like psychosis. These disorders appeared only in part patients with amphetamine dependence. Aim of the study was to establish prevalence of selective risk factors of schizophrenia development in amphetamine users: 1) with amphetamine-induced schizophrenia-like psychosis, 2) with schizophrenia, and 2) w...

Introduction: Amphetamine and methamphetamine are man-made materials. They were only used as drugs at the beginning, but gradually outspreaded as psychedelics because of their sympathomimetic effects. Different studies have shown that the frequency of amphetamine and methamphetamine abuse has been increasing; also, there is a close relationship in amphetamine and methamphetamine abuse with psyc...

We previously demonstrated that rats treated with repeated, intermittent amphetamine displayed enhanced amphetamine-mediated dopamine release in the striatum. In this study, we examined whether amphetamine pretreatment would elicit enhanced amphetamine-mediated dopamine release in a cultured cell line in the absence of intact synaptic connections. PC12 cells pretreated with 1 microM amphetamine...