نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genoty...

Journal: :Journal of medical genetics 1994
M Liddell J Williams A Bayer F Kaiser M Owen

The Apo E genotype of 86 patients with Alzheimer's disease (AD) and 77 age matched controls was determined by digestion of Apo E PCR products with the restriction enzyme CfoI. The frequency of the e4 allele was significantly increased in the patient group (0.33) as compared with controls (0.12). This effect was seen in patients with a family history and in sporadic cases. The odds ratio in homo...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
A J Brown D C Roberts

To determine if apolipoprotein (apo) E polymorphism influences postprandial lipemia and hence can help explain the wide range of lipemic responses to a standardized fat meal observed previously, blood samples were collected from 25 healthy men whose postprandial responses to a standardized fat meal had been measured. Venous blood samples had been obtained before the fat meal (0.73 g fat/kg cont...

Journal: :Annals of hepatology 2015
Erika Martinez-Lopez Fatima Curiel-Lopez Alejandro Hernandez-Nazara Laura E Moreno-Luna Martha E Ramos-Marquez Sonia Roman Arturo Panduro

BACKGROUND Gallstone disease (GSD) is a common chronic disease in the Western hemisphere, yet environmental and genetic factors may be responsible for the variations in the prevalence of GSD among populations. AIM To analyze the relationship of the ApoE and FABP2 polymorphisms with diet, physical activity and emotional health in patients with GSD from West Mexico. MATERIAL AND METHODS A tot...

Journal: :Stroke 1993
A M Saunders A D Roses

Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 1, 000 words (excluding references) and may be subject to editing or abridgment. Please submit Letters to the Editor in duplicate, typed double-spaced. Include an appropriate title and a fax number for the corresponding author. The American Heart Association requires that all autho...

2013
ENGIN KORKMAZER EMIN USTUNYURT BAŞAR TEKIN OGUZ CILINGIR

The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their Apo E genotypes, based on restriction fragment length polymorphism analysis o...

Journal: :Atherosclerosis 1996
S J Bredie J M Vogelaar P N Demacker A F Stalenhoef

The impact of apo E polymorphism on interindividual variation in plasma lipid, lipoprotein concentrations, and LDL subfraction profiles was studied in 201 well-defined patients (88 men and 103 women) with familial combined hyperlipidemia (FCH). When corrected for the concomitant influences of age, gender and obesity, the allelic variation in the apo E gene was shown to explain a statistically s...

Journal: :Journal of Korean Medical Science 1993
Y. S. Kim J. R. Paeng J. T. Woo S. W. Kim I. M. Yang J. W. Kim K. W. Kim Y. K. Choi

Apolipoprotein E (apo E) plays a role in the regulation of the lipid metabolism of humans. Apo E, 229 amino acid polypeptide, is classified into three major isoform (E2, E3, E4) according to the differences of amino acid in position 112 and 158. In the normal population apo E3 isoform is most prevalent and apo E2 or E4 is frequently associated with hyperlipoproteinemia. To find out the frequenc...

Journal: :Physiological genomics 2000
J M Hagberg K R Wilund R E Ferrell

Apolipoprotein E (apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major apo E isoforms are encoded by three common alleles at the APO E locus. The E2 allele is associated with lower and the E4 allele with higher total plasma cholesterol and LDL cholesterol levels compared with the E3 allele. Available data generally indicate...

Journal: :The Journal of clinical investigation 1996
N Bergeron R J Havel

The postprandial responses of apo B48, B100, E and lipids in triglyceride-rich lipoproteins (TRL) to a meal containing one-third of daily energy (39% fat calories) were compared in normolipidemic young men with apo E3/3 and apo E4/3 phenotypes. After the two groups consumed a diet rich in polyunsaturated fat for 15-29 d, their postabsorptive concentrations of TRL triglycerides, apo B48, and apo...

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