SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subj...

The dissociation between magnetic resonance imaging (MRI) and permanent disability in multiple sclerosis (MS), termed the clinicoradiological paradox, can primarily be attributed to the lack of specificity of conventional, relaxivity-based MRI measurements in detecting axonal damage, the primary pathological correlate of long-term impairment in MS. Diffusion tensor imaging (DTI) has shown promi...

We have developed microdensitometer-computer correlation techniques to analyze the arrangement of microtubule arms and bridges (i.e., microtubule-associated proteins [MAPs]). A microdensitometer was used to scan immediately adjacent to the wall of longitudinally sectioned microtubules in positive transparency electron micrographs. Signal enhancement procedures were applied to the digitized dens...

We have demonstrated a novel Fourier-domain optical coherence tomography system and signal-processing algorithm for full-range, real-time, artifact-free quantitative imaging of the anterior chamber. Cross-sectional full-range images comprising 1024 x 800 pixels (axial x lateral) were acquired and displayed at 6.7 images/s. Volumetric data comprising 1024 x 400 x 60 pixels (axial x lateral x ele...

FIG. 4: IBAT FF for the two groups, showing a significant 12% lower FF in the 19°C mice. Note evident variations in the example axial FF maps of IBAT (arrows, same color bar as FIG.1). 25.5°C 19°C FIG. 1: (a) Axial fat fraction map with interscapular BAT (arrow) and a reference cryosection slice. (b) Peri-renal BAT surrounding the kidneys (+), with coronal fat fraction maps overlaid on top of w...

ABSTRACT Local measurements and 3-D CFD simulations in GasLiquid cylindrical Cyclone (GLCC) separators are scarce. The main objective of this study is to conduct local measurements and 3-D CFD simulations to understand the swirling flow behavior in a cylindrical cyclone with one inclined tangential inlet. Axial and tangential velocities and turbulent intensities across the GLCC diameter (ID=3.5...

The fewest-line axial map, often simply referred to as the `axial map', is one of the primary tools of space syntax. Its natural language definition has allowed researchers to draw consistent maps that present a concise description of architectural space; it has been established that graph measures obtained from the map are useful for the analysis of pedestrian movement patterns and activities ...