background: activated platelets shed microparticles (mps) in vivo and certainly in vitro under storage. like platelets, platelet-derived mps contribute to hemostatic and inflammatory responses. we sought to determine the interactions between platelet mps and peripheral b lymphocytes in the healthy blood circulation to propose a possible role for platelet mps in the functioning of b cells.   mat...

The B cell is a vital contributor to humoral immunity. The B cell-specific antigen CD20 is expressed during B cell development, starting at the pre-B cell level and persists through B cell differentiation, but is lost during terminal differentiation to plasma cells. Rituximab is a monoclonal antibody that destroys both normal and malignant B cells that have CD20 on their surfaces and is ther...

Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as -common family have an essential cytokines may support either synergistically or in an additive m...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

background: mesenchymal stem cells (msc) have ability to regulate immune response via proinflamatory cytokines. in this study we aimed to investigate the effect of different mechanism for t cell activation and adjacency on immunoregulatory properties of msc. methods: bone marrow mscs were purchased and t cells were obtained from whole blood sample. t cells were activated by two different mechan...

alcoholic liver disease (ald) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. the etiopathogenesis of ald is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate kupffer cells. curcumin is an active ingredient of the rhizome of turmeric. the...

The relationship between the immunoglobulin (Ig) nucleotide sequence and the ability of a B cell to develop into a malignant cell was studied in a subset of B cells, B-1 cells. B-1 cells become malignant in chronic lymphocytic leukemia (CLL) and are responsible for the production of "natural autoanti‌bodies". The autoimmune NZB mouse has been known as a human malignancy and CLL model, be‌cause ...

Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investiga...