Abstract Background The misuse of illicit substances is associated with increased morbidity and mortality; thus, substance abuse a global health concern. Arabian Gulf region considered crossing point consumer drugs. However, lack laboratory-based research has limited the scientific assessment drug in region. Thus, an up-to-date analytical representation situation warranted. Methods We investiga...

BACKGROUND Often, long-term treatment with benzodiazepines is a subject of discussion due to potential side effects, with dependence on benzodiazepines as the most serous one. After longer period of benzodiazepines tolerance on their anxiolytic effects develops. Discontinuation is usually beneficial as it is followed by improved psychomotor and cognitive functioning, particularly in the elderly...

Benzodiazepines are widely prescribed drugs used to treat anxiety and insomnia, induce muscle relaxation, control epileptic seizures, promote anaesthesia or produce amnesia. Benzodiazepines are also abused for recreational purposes and the number of benzodiazepine abusers is unfortunately increasing. Within weeks of chronic use, tolerance to the pharmacological effects can develop and withdrawa...

From an historical standpoint, the development of our understanding of basic mechanisms of the actions of gamma aminobutyric acid (GABA) and benzodiazepines began on separate paths. Classical pharmacology revealed similarity between the actions of GABA and benzodiazepines in the central nervous system. Furthermore, pharmacological experiments with selective agonists and antagonists indicated th...

Objective: Benzodiazepines are a widely used class of medications for anxiety, depression, and insomnia. Despite their common use, concerns remain about memory problems with benzodiazepines. the growing financial social burden dementia, inconsistent results persist regarding association between benzodiazepines dementia. Therefore, we aimed to evaluate dementia in Korea. Methods: Diagnostic pres...

Objective: Benzodiazepines are a group of psychotropic drugs that are frequently prescribed. There are many published studies indicate that these drugs can affect driving ability. These studies are either epidemiological or experimental. Some efforts have been made recently toward the establishment of legal limits for benzodiazepines in the blood of drivers. Methods: A systematic review of the ...

background: the aim of this study was to evaluate and compare the clinical and ‎electrocardiographic (ecg) manifestations of benzodiazepines (bzs).‎ methods: in this retrospective study, all bz-poisoned patients hospitalized at loghman ‎hakim hospital between september 2010 and march 2011 were evaluated. patients’ ‎information including age, sex, time elapsed between the ingestion and presentat...

Prescribe Benzodiazepines? Not Me! Modern guidelines for psychopharmacologic treatment of anxiety disorders have evolved from recommending GABAergic (gammaaminobutryic acid) benzodiazepines to recommending serotonergic agents for first-line use. This trend, along with adverse publicity about the dependence potential of benzodiazepines, might lead one to suspect that benzodiazepines, once promin...

Background & Objective: Some drugs like benzodiazepines have been associated with an increased incidence of infections by making weak immune system. Here, we determined the effect of use of benzodiazepines on the occurrence of community acquired pneumonia (CAP). Methods: We used Taiwan National Health Insurance Claim Database of 22 million (2002) population to investigate the association of ben...

conformations and electronic properties of a series of imidazobenzodiazepines are investigated by am1 semi-empirical quantum mechanics method. it is shown that substitution of cl in position 7 instead of 8, changes the geometry of the seven membered lactam ring; this may put the n5 nitrogen in a better positon to act as a hydrogen bond acceptor, and the phenyl ring in position 6 is probably mor...