Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar...

UNLABELLED Several bone-seeking radionuclides (32P, 89Sr, 186Re, and 153Sm) have been used to treat bone pain. The limiting factor in this modality is marrow toxicity. Our hypothesis is that marrow toxicity can be reduced while maintaining therapeutic efficacy using radionuclides that emit short-range beta particles or conversion electrons (CEs). A recent study on 47 patients using the short-ra...

Introduction: Internal exposure to radon gas progeny can lead to serious biologic damages to the lung tissue. The aim of this study was to evaluate the absorbed dose by lung tissue due to the exposure from short-lived radioactive products of radon (222Rn) decay using Monte Carlo simulation. Material and Methods: A lung equivalent p...

UNLABELLED Ex vivo autoradiographs of healthy kidney tissue from patients who received (111)In-DTPA-octreotide (DTPA is diethylenetriaminepentaacetic acid) before nephrectomy showed very heterogeneous radioactivity patterns in the kidneys. The consequences of the reported inhomogeneities have been evaluated for radionuclide therapy with (90)Y- DOTA-Tyr(3)-octreotide (DOTA is 1,4,7,10-tetraazacy...

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...

Introduction: Spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. At present, the main source of data for cellular dosimetry is the s-values provided by MIRD. However, the MIRD s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. In this study, we used Geant4-DNA...

The low-level salt waste (LAW) associated with the production of nuclear materials at US Department of Energy (DOE) facilities will be disposed of in shallow land burial sites managed by the DOE. Two of the primary contaminants of interest are Tc-99 and I-129, both soluble and long-lived radionuclides. Cs-137, a short-lived, strong gamma emitter is also a soluble contaminant of concern. In addi...

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...

Abstract A need for method validation in radiochemical analyses of decommissioning waste is a challenging task due to lack commercial reference materials. Participation an intercomparison exercise one way laboratory assess their performance and validate analysis results. three-year project within the Nordic Nuclear Safety Research (NKS) community was initiated order carry out exercises on diffi...