نتایج جستجو برای: biological availability
تعداد نتایج: 593086 فیلتر نتایج به سال:
The concept of drug-likeness helps to optimise pharmacokinetic and pharmaceutical properties, for example, solubility, chemical stability, bioavailability and distribution profile. A number of molecular descriptors have emerged as reasonably informative and predictive, for example, the Rule-of-Five. Here, we review some current approaches, then discuss their major shortcoming, namely the static...
Introduction Conclusions References
Poorly water soluble molecules are typically formulated for improving their dissolution rate and storage stability by increasing active drug surface area that come in the contact with the dissolution medium [4]. Most important characteristics of nanosuspensions are their exhibited particle size; polydispersity index, drug saturation solubility, physical stability, dissolution rate and bioavaila...
Objective(s): Curcuminoids, comprising curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), are bioactive phytochemicals with numerous pharmacological effects. Oral biological availability of curcuminoids is low due to the low aqueous solubility and rapid metabolism. This study aimed at fabricating a nanomicellar curcuminoid formula with enhanced pharmacokinetic properties. Materi...
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