Introduction: Bisphenol A (BPA) is a toxic chemical that is used as a monomer in the production of plastic products. The BPA has an endocrine-disrupting effect and ‎induces damage to the nervous system. Crocin, an active ingredient of Crocus sativus L. has ‎neuroprotective effects. Therefore, this study aimed to evaluate crocin’s effects on BPA-induced ‎memory impairment in rats and the levels ...

The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were comparatively examined by means of different in vitro and in vivo reporter assays. BPA and some related compounds exhibited estrogenic activity in human breast cancer cell line MCF-7, but there were remarkable differences in activity. Tetrachlorobisphenol A (TCBPA) showed the highest activity, followed by bis...

On behalf of the Polycarbonate/BPA Global Group of the American Chemistry Council (ACC), I am submitting these comments in response to OEHHA’s Notice of Proposed Rulemaking regarding the proposed Maximum Allowable Dose Level (MADL) for bisphenol A (BPA). The Polycarbonate/BPA Global Group consists of the leading global manufacturers of BPA and polycarbonate plastic, which for many years have su...

Bisphenol A (BPA) is an industrial chemical produced in large volumes. Its main use is associated with polycarbonate plastic, epoxy resins and thermal paper. In contrast to other applications, thermal paper contains BPA in its un-reacted form as an additive, which is subjected to migration. Receiving a significant amount of attention from the scientific community and beyond, due to its controve...

An overview of the low dose effects of Bisphenol A in relation to breast cancer

AIM The aim of this study was to investigate whether environmental endocrine-disrupting chemicals, bisphenol A (BPA) and BPA-related chemicals, affect adiponectin production and secretion in 3T3-L1 adipocytes and whether BPA acts through Akt signaling. METHODS 3T3-L1 adipocytes were treated for 24 h with BPA at various concentrations (20-80 microM) in serum-deprived medium. The medium was fil...

Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus ...

Bisphenol-A (BPA) is widely used in the plastic industry, and it is one of the well-studied endocrine disrupting chemicals (EDCs). Growing evidence raised the concern of BPA having weak estrogenic activity on human health including female reproductive functions and diseases. Serum BPA level is also associated with pregnancy loss, reproductive tract diseases and infertility. In fact, several cou...

results the main pathological finding observed in the prostrate and seminal vesicle glands, using light microscope, revealed congestion in the connective tissue and vacuolization in the secretory units of epithelial cells and epithelium rupture at 50 and 100 µg/kg doses of bpa. ultrastructure study showed vacuolization of mitochondria, condensation of nuclei and disappearance of nucleus in the ...

Considerable concerns about bisphenol A (BPA) as a potential endocrine disruptor remain controversial among dentists and patients due to the study of Olea et al. (1). Their study has frequently been mentioned in scientific papers as well as in the mass media, popular journals, and books. When I read the paper, I was shocked to find unscientific data related to high performance liquid chromatogr...