Utsumi, Hiroyuki, Hideki Chiba, Yasuhiro Kamimura, Makoto Osanai, Yo Igarashi, Hirotoshi Tobioka, Michio Mori, and Norimasa Sawada. Expression of GFRa-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB. Am J Physiol Cell Physiol 279: C361–C368, 2000.—It is well known that the bloodbrain barrier (BBB) matures at ;2 wk after birth in the rat. Recently, we showed ...

Viewer/Itinerary Planner. Society for Neuroscience. Washington, DC, USA. http://sfn.scholarone.com. 44. Zhang, Z.G., et al. 2000. VEGF enhances angiogenesis and promotes bloodbrain barrier leakage in the ischemic brain. J. Clin. Invest. 106:829–838.

In a clinical study conducted a decade ago, it was proposed that different versions of the gene encoding phosphodiesterase 4D, cAMP-specific (pde4d) confer different risks for ischemic stroke. Today, however, there continues to be unresolved global discussion of this issue. This short review summarizes the results of clinical genomic and basic research studies. In the acute phase following expe...

It is known that circumventricular organs that are located around the ventricular system of the brain are lack of blood-brain barrier and support the body water-salt balance. They also effect many physiological events such as some neuroendocrine and reproduction mechanisms. In different pathological conditions their results and the step in which the circumventricular organs are affected are unk...

We present the review of clinical and experimental studies on pathogenesis neurorheumatological complications (NRC) in COVID-19. The influence systemic hyperinflammation caused by impaired innate immunity functioning neurovascular endothelium bloodbrain barrier, activation signaling pathways parainfectious autoimmunity central nervous system were analyzed. Hyperinflammation has been shown to co...

The final part of the review focuses on existing methods and results studying effects nanoparticles (NPs) brain behavior. types behavioral tests used to assess changes in behavior NP-treated animals are described. data accumulated literature negative influence NPs animal brains exposed adulthood considered. signs different cellular tissue damage presented, such as development oxidative stress b...

in this research, high oxygen-barrier films were organized based on low-density polyethylene (ldpe)/ ethylene vinyl alcohol (evoh)/ polyethylene-grafted maleic anhydride (ldpe-g-ma) compatibilizer. the effects of 10–30 wt. % evoh and 0–10 wt. % ldpe-g-ma loadings on the properties of final films were evaluated. the morphology of specimens was observed by using scanning electron microscopy (sem)...

Background: In acute ischemic stroke (AIS) patients, damage to the bloodbrain barrier (BBB) can ultimately lead to the most feared complication of thrombolytic therapy, intracranial hemorrhage (ICH). MRI evidence of breakdown in the BBB has been linked to subsequent ICH in animals and in humans. Recent studies have demonstrated that leakage of contrast during PWI of AIS patients due to increase...