Purpose Recent studies indicate that the amount of deformation of the peripapillary retinal pigment epithelium and Bruch's membrane (pRPE/BM) toward or away from the vitreous may reflect acute changes in cerebrospinal fluid pressure. The study purpose is to determine if changes in optic-nerve-head (ONH) shape reflect a treatment effect (acetazolamide/placebo + weight management) using the optic...

Objective(s):Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. Materials and Methods:Adult male Wistar rats were divided into control and te...

Isolated optic nerve involvement is rarely reported as an initial site of relapse after complete systemic remission of childhood acute lymphoblastic leukemia. In such cases, a full ophthalmologist exploration, radiologic investigations and a complete disease evaluation including cerebral spinal fluid and bone marrow studies with molecular evaluation of minimal residual disease have to be immedi...

Abstract PURPOSE Stereotactic radiosurgery (SRS) has become the mainstay to treat BM. Follow-up MRI provides important information on lesion treatment response and guides future therapy planning. Volumetric measurements of BM have shown promise over traditional uni- two-dimensional in more accurate repeatable assessment. However, routine clinical use yet be achieved because workflow is laboriou...

Abstract The incidence of brain metastases (BM) in non-small cell lung cancer (NSCLC) patients is continuously increasing. recent improvements systemic treatment NSCLC necessitate continuous updates on prognostic subgroups and factors determining overall survival. In order to improve clinical decision-making, we investigated the determinants affecting survival with resectable BM. A retrospectiv...

Bullous pemphigoid antigen 2 (BPAG2) is targeted by autoantibodies in patients with bullous pemphigoid (BP), and absent in patients with one type of epidermolysis bullosa (OMIM #226650). A keratin 14 promoter construct was used to produce transgenic (Tg) mice appropriately expressing human BPAG2 (hBPAG2) in murine epidermal basement membrane (BM). Grafts of Tg skin placed on gender-matched, syn...

Osteoclasts (OC), specialized cells derived from monocytes, maintain skeletal homeostasis under normal conditions but degrade bone in patients with rheumatoid (RA) and psoriatic arthritis (PsA). Monocytes initially develop in the bone marrow (BM), circulate in peripheral blood, and differentiate into distinct cell types with diverse functions. Imaging studies in (RA) patients and murine arthrit...

BACKGROUND Both Gamma-Knife radiosurgery (GKRS) and BRAF inhibitors (BRAF-I) have been shown to be useful in melanoma patients with brain metastases (BMs), thus suggesting that it could be interesting to combine their respective advantages. However, cases of radiosensitization following conventional radiation therapy in BRAF-I treated patients have raised serious concerns about the real feasibi...