BACKGROUND The presence of cytokeratin (CK)-positive cells in the bone marrow (BM) of breast cancer patients is an independent prognostic marker for long-term survival. While the exact nature of these cells remains under investigation, their persistence after chemotherapy is linked to decreased survival, making them a potential therapeutic target. Targeted therapy using the her2 antibody has be...

We report a detailed longitudinal study of the first patient to be treated (in 1973) for paroxysmal nocturnal hemoglobinuria (PNH) with syngeneic bone marrow transplantation (BMT). The patient subsequently relapsed with PNH in 1983, and still has PNH to date. Analysis of the PIG-A gene in a recent blood sample showed in exon 6 an insertion-duplication causing a frameshift. Polymerase chain reac...

INTRODUCTION Airway inflammation and remodeling are well recognized features of asthma. Remodeling is usually regarded as a consequence of chronic inflammation, however there are also data suggesting that remodeling is a relatively independent process in asthma. Neither inflammation nor remodeling is a uniform process. Thus the precise relationship between markers of inflammation and different ...

statement of problem: odontogenic keratocysts (okc) make up 10-12% of all developmental cysts with dental origin. okcs are classified into parakeratotic and orthokeratotic types, with completely different clinical features. in order to investigate biological behavior of okcs, an immunohistochemical study was designed, using ki-67 antigen as proliferation marker and p53 protein as tumor suppress...

BACKGROUND Immunophenotyping is a valuable ancillary technique for the differential diagnosis between myelodysplastic syndromes (MDS) with low bone marrow (BM) blast counts and a normal karyotype, and reactive peripheral (PB) cytopenias. Our aim was to search for the most important variables for this purpose. We also analyzed the age variation of BM B-cell precursors (BCP) and its differences i...

INTRODUCTION Airway remodeling is a characteristic feature of asthma. It is believed that airway remodeling affects lung function and bronchial hyper-responsiveness. Therefore, the relationship between remodeling and lung function is still a matter of extensive research. However, the results of many studies are inconsistent. The aim of the study was to assess the relationship between lung funct...

PURPOSE To assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length. METHODS Human globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histol...

Dear Editor, Refractory cytopenia of childhood (RCC) is the most common subtype of hypoplastic myelodysplastic syndrome (hMDS) in childhood, characterized by persistent cytopenia, dysplastic changes in erythroid precursors or megakaryocytes, and the presence of erythroid islands, defined as more than 10 erythroid precursors in a bone marrow (BM) biopsy section [1, 2]. Since 75% of the patients ...