China is experiencing a syphilis epidemic of enormous proportions. The regions most heavily affected by syphilis correspond to regions where sexually transmitted HIV infection is also a major public health threat. Many high-risk patients in China fail to receive routine syphilis screening. This missed public health opportunity stems from both a failure of many high-risk individuals to seek clin...

Application of the Next generation sequencing (NGS) technology has demonstrated that most tumor samples exhibit intra-tumor heterogeneity. Here we proposed SAPPH (Somatic Aberrations Prediction for Paired Heterogeneous tumor samples), as a new method for estimating tumor somatic copy number aberrations as well as inferring tumor subclone proportions from heterogeneous tumor sequencing data. Thi...

We suggest that the conventional need for overwhelming amounts of astrophysical dark matter should be regarded as a warning to standard gravity rather than as merely a challenge to it, and show that the systematics of galactic rotation curve data can just as readily point in the direction of the equally covariant conformal gravity alternative. In particular we identify an apparent imprint of th...

Obesity is a disorder of the nutritional status characterized by excessive accumulation of fat in the subcutaneous tissue and / or other tissues as a result of energy imbalance. 1 Leptin, the most important anorexigenic hormone is secreted by the adipose tissue, acts directly on the satiety and hunger center localized in the anterior hypothalamus and arcuate nucleus. 2 Body mass index (BMI) is ...